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Antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging

Sarcopenia is a degenerative condition that consists in age-induced atrophy and functional decline of skeletal muscle cells (myofibers). A common hypothesis is that inducing myofiber hypertrophy should also reinstate myofiber contractile function but such model has not been extensively tested. Here,...

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Detalles Bibliográficos
Autores principales:	Hunt, Liam C., Schadeberg, Bronwen, Stover, Jared, Haugen, Benard, Pagala, Vishwajeeth, Wang, Yong-Dong, Puglise, Jason, Barton, Elisabeth R., Peng, Junmin, Demontis, Fabio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930053/ https://www.ncbi.nlm.nih.gov/pubmed/33658508 http://dx.doi.org/10.1038/s41467-021-21738-8

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