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Intraoperative Brain Mapping by Cortico-Cortical Evoked Potential

To preserve postoperative brain function, it is important for neurosurgeons to fully understand the brain's structure, vasculature, and function. Intraoperative high-frequency electrical stimulation during awake craniotomy is the gold standard for mapping the function of the cortices and white...

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Autores principales: Yamao, Yukihiro, Matsumoto, Riki, Kikuchi, Takayuki, Yoshida, Kazumichi, Kunieda, Takeharu, Miyamoto, Susumu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930065/
https://www.ncbi.nlm.nih.gov/pubmed/33679353
http://dx.doi.org/10.3389/fnhum.2021.635453
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author Yamao, Yukihiro
Matsumoto, Riki
Kikuchi, Takayuki
Yoshida, Kazumichi
Kunieda, Takeharu
Miyamoto, Susumu
author_facet Yamao, Yukihiro
Matsumoto, Riki
Kikuchi, Takayuki
Yoshida, Kazumichi
Kunieda, Takeharu
Miyamoto, Susumu
author_sort Yamao, Yukihiro
collection PubMed
description To preserve postoperative brain function, it is important for neurosurgeons to fully understand the brain's structure, vasculature, and function. Intraoperative high-frequency electrical stimulation during awake craniotomy is the gold standard for mapping the function of the cortices and white matter; however, this method can only map the “focal” functions and cannot monitor large-scale cortical networks in real-time. Recently, an in vivo electrophysiological method using cortico-cortical evoked potentials (CCEPs) induced by single-pulse electrical cortical stimulation has been developed in an extraoperative setting. By using the CCEP connectivity pattern intraoperatively, mapping and real-time monitoring of the dorsal language pathway is available. This intraoperative CCEP method also allows for mapping of the frontal aslant tract, another language pathway, and detection of connectivity between the primary and supplementary motor areas in the frontal lobe network. Intraoperative CCEP mapping has also demonstrated connectivity between the frontal and temporal lobes, likely via the ventral language pathway. Establishing intraoperative electrophysiological monitoring is clinically useful for preserving brain function, even under general anesthesia. This CCEP technique demonstrates potential clinical applications for mapping and monitoring large-scale cortical networks.
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spelling pubmed-79300652021-03-05 Intraoperative Brain Mapping by Cortico-Cortical Evoked Potential Yamao, Yukihiro Matsumoto, Riki Kikuchi, Takayuki Yoshida, Kazumichi Kunieda, Takeharu Miyamoto, Susumu Front Hum Neurosci Human Neuroscience To preserve postoperative brain function, it is important for neurosurgeons to fully understand the brain's structure, vasculature, and function. Intraoperative high-frequency electrical stimulation during awake craniotomy is the gold standard for mapping the function of the cortices and white matter; however, this method can only map the “focal” functions and cannot monitor large-scale cortical networks in real-time. Recently, an in vivo electrophysiological method using cortico-cortical evoked potentials (CCEPs) induced by single-pulse electrical cortical stimulation has been developed in an extraoperative setting. By using the CCEP connectivity pattern intraoperatively, mapping and real-time monitoring of the dorsal language pathway is available. This intraoperative CCEP method also allows for mapping of the frontal aslant tract, another language pathway, and detection of connectivity between the primary and supplementary motor areas in the frontal lobe network. Intraoperative CCEP mapping has also demonstrated connectivity between the frontal and temporal lobes, likely via the ventral language pathway. Establishing intraoperative electrophysiological monitoring is clinically useful for preserving brain function, even under general anesthesia. This CCEP technique demonstrates potential clinical applications for mapping and monitoring large-scale cortical networks. Frontiers Media S.A. 2021-02-18 /pmc/articles/PMC7930065/ /pubmed/33679353 http://dx.doi.org/10.3389/fnhum.2021.635453 Text en Copyright © 2021 Yamao, Matsumoto, Kikuchi, Yoshida, Kunieda and Miyamoto. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Human Neuroscience
Yamao, Yukihiro
Matsumoto, Riki
Kikuchi, Takayuki
Yoshida, Kazumichi
Kunieda, Takeharu
Miyamoto, Susumu
Intraoperative Brain Mapping by Cortico-Cortical Evoked Potential
title Intraoperative Brain Mapping by Cortico-Cortical Evoked Potential
title_full Intraoperative Brain Mapping by Cortico-Cortical Evoked Potential
title_fullStr Intraoperative Brain Mapping by Cortico-Cortical Evoked Potential
title_full_unstemmed Intraoperative Brain Mapping by Cortico-Cortical Evoked Potential
title_short Intraoperative Brain Mapping by Cortico-Cortical Evoked Potential
title_sort intraoperative brain mapping by cortico-cortical evoked potential
topic Human Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930065/
https://www.ncbi.nlm.nih.gov/pubmed/33679353
http://dx.doi.org/10.3389/fnhum.2021.635453
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