Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation

Staphylococcus aureus is a prominent human pathogen that readily adapts to host immune defenses. Here, we show that, in contrast to Gram-negative pathogens, S. aureus induces a distinct airway immunometabolic response dominated by the release of the electrophilic metabolite, itaconate. The itaconate...

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Detalles Bibliográficos
Autores principales: Tomlinson, Kira L., Lung, Tania Wong Fok, Dach, Felix, Annavajhala, Medini K., Gabryszewski, Stanislaw J., Groves, Ryan A., Drikic, Marija, Francoeur, Nancy J., Sridhar, Shwetha H., Smith, Melissa L., Khanal, Sara, Britto, Clemente J., Sebra, Robert, Lewis, Ian, Uhlemann, Anne-Catrin, Kahl, Barbara C., Prince, Alice S., Riquelme, Sebastián A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930111/
https://www.ncbi.nlm.nih.gov/pubmed/33658521
http://dx.doi.org/10.1038/s41467-021-21718-y

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