Synthesis of tetrazolo[1,5-a]pyrimidine-6-carbonitriles using HMTA-BAIL@MIL-101(Cr) as a superior heterogeneous catalyst

A one-pot three component reaction of benzaldehydes, 1H-tetrazole-5-amine, and 3-cyanoacetyl indole in the presence of a new hexamethylenetetramine-based ionic liquid/MIL-101(Cr) metal–organic framework as a recyclable catalyst was explored. This novel catalyst, which was fully characterized by XRD,...

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Autores principales: Abdollahi-Basir, Mohammad Hossein, Mirhosseini-Eshkevari, Boshra, Zamani, Farzad, Ghasemzadeh, Mohammad Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930133/
https://www.ncbi.nlm.nih.gov/pubmed/33658548
http://dx.doi.org/10.1038/s41598-021-84379-3
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author Abdollahi-Basir, Mohammad Hossein
Mirhosseini-Eshkevari, Boshra
Zamani, Farzad
Ghasemzadeh, Mohammad Ali
author_facet Abdollahi-Basir, Mohammad Hossein
Mirhosseini-Eshkevari, Boshra
Zamani, Farzad
Ghasemzadeh, Mohammad Ali
author_sort Abdollahi-Basir, Mohammad Hossein
collection PubMed
description A one-pot three component reaction of benzaldehydes, 1H-tetrazole-5-amine, and 3-cyanoacetyl indole in the presence of a new hexamethylenetetramine-based ionic liquid/MIL-101(Cr) metal–organic framework as a recyclable catalyst was explored. This novel catalyst, which was fully characterized by XRD, FE-SEM, EDX, FT-IR, TGA, BET, and TEM exhibited outstanding catalytic activity for the preparation of a range of pharmaceutically important tetrazolo[1,5-a]pyrimidine-6-carbonitriles with good to excellent yields in short reaction time.
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spelling pubmed-79301332021-03-05 Synthesis of tetrazolo[1,5-a]pyrimidine-6-carbonitriles using HMTA-BAIL@MIL-101(Cr) as a superior heterogeneous catalyst Abdollahi-Basir, Mohammad Hossein Mirhosseini-Eshkevari, Boshra Zamani, Farzad Ghasemzadeh, Mohammad Ali Sci Rep Article A one-pot three component reaction of benzaldehydes, 1H-tetrazole-5-amine, and 3-cyanoacetyl indole in the presence of a new hexamethylenetetramine-based ionic liquid/MIL-101(Cr) metal–organic framework as a recyclable catalyst was explored. This novel catalyst, which was fully characterized by XRD, FE-SEM, EDX, FT-IR, TGA, BET, and TEM exhibited outstanding catalytic activity for the preparation of a range of pharmaceutically important tetrazolo[1,5-a]pyrimidine-6-carbonitriles with good to excellent yields in short reaction time. Nature Publishing Group UK 2021-03-03 /pmc/articles/PMC7930133/ /pubmed/33658548 http://dx.doi.org/10.1038/s41598-021-84379-3 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Abdollahi-Basir, Mohammad Hossein
Mirhosseini-Eshkevari, Boshra
Zamani, Farzad
Ghasemzadeh, Mohammad Ali
Synthesis of tetrazolo[1,5-a]pyrimidine-6-carbonitriles using HMTA-BAIL@MIL-101(Cr) as a superior heterogeneous catalyst
title Synthesis of tetrazolo[1,5-a]pyrimidine-6-carbonitriles using HMTA-BAIL@MIL-101(Cr) as a superior heterogeneous catalyst
title_full Synthesis of tetrazolo[1,5-a]pyrimidine-6-carbonitriles using HMTA-BAIL@MIL-101(Cr) as a superior heterogeneous catalyst
title_fullStr Synthesis of tetrazolo[1,5-a]pyrimidine-6-carbonitriles using HMTA-BAIL@MIL-101(Cr) as a superior heterogeneous catalyst
title_full_unstemmed Synthesis of tetrazolo[1,5-a]pyrimidine-6-carbonitriles using HMTA-BAIL@MIL-101(Cr) as a superior heterogeneous catalyst
title_short Synthesis of tetrazolo[1,5-a]pyrimidine-6-carbonitriles using HMTA-BAIL@MIL-101(Cr) as a superior heterogeneous catalyst
title_sort synthesis of tetrazolo[1,5-a]pyrimidine-6-carbonitriles using hmta-bail@mil-101(cr) as a superior heterogeneous catalyst
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930133/
https://www.ncbi.nlm.nih.gov/pubmed/33658548
http://dx.doi.org/10.1038/s41598-021-84379-3
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