Cargando…
Control of Cerebral Blood Flow by Blood Gases
Cerebrovascular reactivity can be measured as the cerebrovascular flow response to a hypercapnic challenge. The many faceted responses of cerebral blood flow to combinations of blood gas challenges are mediated by its vasculature’s smooth muscle and can be comprehensively described by a simple mathe...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930328/ https://www.ncbi.nlm.nih.gov/pubmed/33679453 http://dx.doi.org/10.3389/fphys.2021.640075 |
_version_ | 1783660084092469248 |
---|---|
author | Duffin, James Mikulis, David J. Fisher, Joseph A. |
author_facet | Duffin, James Mikulis, David J. Fisher, Joseph A. |
author_sort | Duffin, James |
collection | PubMed |
description | Cerebrovascular reactivity can be measured as the cerebrovascular flow response to a hypercapnic challenge. The many faceted responses of cerebral blood flow to combinations of blood gas challenges are mediated by its vasculature’s smooth muscle and can be comprehensively described by a simple mathematical model. The model accounts for the blood flow during hypoxia, anemia, hypocapnia, and hypercapnia. The main hypothetical basis of the model is that these various challenges, singly or in combination, act via a common regulatory pathway: the regulation of intracellular hydrogen ion concentration. This regulation is achieved by membrane transport of strongly dissociated ions to control their intracellular concentrations. The model assumes that smooth muscle vasoconstriction and vasodilation and hence cerebral blood flow, are proportional to the intracellular hydrogen ion concentration. Model predictions of the cerebral blood flow responses to hypoxia, anemia, hypocapnia, and hypercapnia match the form of observed responses, providing some confidence that the theories on which the model is based have some merit. |
format | Online Article Text |
id | pubmed-7930328 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79303282021-03-05 Control of Cerebral Blood Flow by Blood Gases Duffin, James Mikulis, David J. Fisher, Joseph A. Front Physiol Physiology Cerebrovascular reactivity can be measured as the cerebrovascular flow response to a hypercapnic challenge. The many faceted responses of cerebral blood flow to combinations of blood gas challenges are mediated by its vasculature’s smooth muscle and can be comprehensively described by a simple mathematical model. The model accounts for the blood flow during hypoxia, anemia, hypocapnia, and hypercapnia. The main hypothetical basis of the model is that these various challenges, singly or in combination, act via a common regulatory pathway: the regulation of intracellular hydrogen ion concentration. This regulation is achieved by membrane transport of strongly dissociated ions to control their intracellular concentrations. The model assumes that smooth muscle vasoconstriction and vasodilation and hence cerebral blood flow, are proportional to the intracellular hydrogen ion concentration. Model predictions of the cerebral blood flow responses to hypoxia, anemia, hypocapnia, and hypercapnia match the form of observed responses, providing some confidence that the theories on which the model is based have some merit. Frontiers Media S.A. 2021-02-18 /pmc/articles/PMC7930328/ /pubmed/33679453 http://dx.doi.org/10.3389/fphys.2021.640075 Text en Copyright © 2021 Duffin, Mikulis and Fisher. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Duffin, James Mikulis, David J. Fisher, Joseph A. Control of Cerebral Blood Flow by Blood Gases |
title | Control of Cerebral Blood Flow by Blood Gases |
title_full | Control of Cerebral Blood Flow by Blood Gases |
title_fullStr | Control of Cerebral Blood Flow by Blood Gases |
title_full_unstemmed | Control of Cerebral Blood Flow by Blood Gases |
title_short | Control of Cerebral Blood Flow by Blood Gases |
title_sort | control of cerebral blood flow by blood gases |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930328/ https://www.ncbi.nlm.nih.gov/pubmed/33679453 http://dx.doi.org/10.3389/fphys.2021.640075 |
work_keys_str_mv | AT duffinjames controlofcerebralbloodflowbybloodgases AT mikulisdavidj controlofcerebralbloodflowbybloodgases AT fisherjosepha controlofcerebralbloodflowbybloodgases |