Cargando…

CD73 Ectonucleotidase Restrains CD8+ T Cell Metabolic Fitness and Anti-tumoral Activity

CD39 and CD73 are ectoenzymes that dephosphorylate ATP into its metabolites; ADP, AMP, and adenosine, and thus are considered instrumental in the development of immunosuppressive microenvironments. We have previously shown that within the CD8+ T cell population, naïve and memory cells express the CD...

Descripción completa

Detalles Bibliográficos
Autores principales:	Briceño, Pedro, Rivas-Yañez, Elizabeth, Rosemblatt, Mariana V., Parra-Tello, Brian, Farías, Paula, Vargas, Leonardo, Simon, Valeska, Cárdenas, César, Lladser, Alvaro, Salazar-Onfray, Flavio, Elorza, Alvaro A., Rosemblatt, Mario, Bono, María Rosa, Sauma, Daniela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930398/ https://www.ncbi.nlm.nih.gov/pubmed/33681221 http://dx.doi.org/10.3389/fcell.2021.638037

Ejemplares similares

Ecto-5′-Nucleotidase (CD73) Regulates the Survival of CD8+ T Cells
por: Rosemblatt, Mariana V., et al.
Publicado: (2021)

P2X7 Receptor at the Crossroads of T Cell Fate
por: Rivas-Yáñez, Elizabeth, et al.
Publicado: (2020)

In Vitro-Generated Tc17 Cells Present a Memory Phenotype and Serve As a Reservoir of Tc1 Cells In Vivo
por: Flores-Santibáñez, Felipe, et al.
Publicado: (2018)

Monitoring and characterizing soluble and membrane-bound ectonucleotidases CD73 and CD39
por: Goueli, Said A., et al.
Publicado: (2019)

The ectonucleotidases CD39 and CD73 on T cells: The new pillar of hematological malignancy
por: Jiang, Xuan, et al.
Publicado: (2023)

IRE1α Activation in Bone Marrow-Derived Dendritic Cells Modulates Innate Recognition of Melanoma Cells and Favors CD8(+) T Cell Priming
por: Medel, Bernardita, et al.
Publicado: (2019)

The Role of Ectonucleotidases CD39 and CD73 and Adenosine Signaling in Solid Organ Transplantation
por: Roberts, Veena, et al.
Publicado: (2014)

Resident Cardiac Immune Cells and Expression of the Ectonucleotidase Enzymes CD39 and CD73 after Ischemic Injury
por: Bönner, Florian, et al.
Publicado: (2012)

Relationship between the Gene Expression of Adenosine Kinase Isoforms and the Expression of CD39 and CD73 Ectonucleotidases in Colorectal Cancer
por: Zhulai, G. A., et al.
Publicado: (2023)

Nucleotide Analog ARL67156 as a Lead Structure for the Development of CD39 and Dual CD39/CD73 Ectonucleotidase Inhibitors
por: Schäkel, Laura, et al.
Publicado: (2020)

Alloreactive Regulatory T Cells Allow the Generation of Mixed Chimerism and Transplant Tolerance
por: Ruiz, Paulina, et al.
Publicado: (2015)

The Multifaceted Roles of B Cells in the Thymus: From Immune Tolerance to Autoimmunity
por: Castañeda, Justine, et al.
Publicado: (2021)

Retinoic Acid as a Modulator of T Cell Immunity
por: Bono, Maria Rosa, et al.
Publicado: (2016)

Downregulation of the 5’-ectonucleotidase CD73 of CD8+ CTL of HIV infected patients correlates with immune activation and diminished IL-2 production
por: Toth, I, et al.
Publicado: (2012)

HPV-16 Infection Is Associated with a High Content of CD39 and CD73 Ectonucleotidases in Cervical Samples from Patients with CIN-1
por: de Lourdes Mora-García, María, et al.
Publicado: (2019)

Characterization of Ectonucleotidases in Human Medulloblastoma Cell Lines: ecto-5′NT/CD73 in Metastasis as Potential Prognostic Factor
por: Cappellari, Angélica Regina, et al.
Publicado: (2012)

Correction: Characterization of Ectonucleotidases in Human Medulloblastoma Cell Lines: ecto-5′NT/CD73 in Metastasis as Potential Prognostic Factor
por: Cappellari, Angélica Regina, et al.
Publicado: (2012)

Adoptive transfer of autoimmune splenic dendritic cells to lupus-prone mice triggers a B lymphocyte humoral response
por: Sauma, Daniela, et al.
Publicado: (2017)

Phenotypic and functional alterations of peritoneal macrophages in lupus-prone mice
por: Tejon, Gabriela, et al.
Publicado: (2022)

The Inhibition of CD39 and CD73 Cell Surface Ectonucleotidases by Small Molecular Inhibitors Enhances the Mobilization of Bone Marrow Residing Stem Cells by Decreasing the Extracellular Level of Adenosine
por: Adamiak, Mateusz, et al.
Publicado: (2019)

5ʹ-Ectonucleotidase CD73/NT5E supports EGFR-mediated invasion of HPV-negative head and neck carcinoma cells
por: Shi, Enxian, et al.
Publicado: (2023)

Ectonucleotidase activity and immunosuppression in astrocyte-CD4 T cell bidirectional signaling
por: Filipello, Fabia, et al.
Publicado: (2016)

MET-Induced CD73 Restrains STING-Mediated Immunogenicity of EGFR-Mutant Lung Cancer
por: Yoshida, Ryohei, et al.
Publicado: (2022)

Vaccination-induced skin-resident memory CD8(+) T cells mediate strong protection against cutaneous melanoma
por: Gálvez-Cancino, Felipe, et al.
Publicado: (2018)

Purinergic Signaling as a Regulator of Th17 Cell Plasticity
por: Fernández, Dominique, et al.
Publicado: (2016)

Ectonucleotidase CD39 is highly expressed on ATLL cells and is responsible for their immunosuppressive function
por: Nagate, Yasuhiro, et al.
Publicado: (2020)

Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance
por: Ruiz, Paulina, et al.
Publicado: (2013)

NTPDase1/CD39 Ectonucleotidase Is Necessary for Normal Arterial Diameter Adaptation to Flow
por: Favre, Julie, et al.
Publicado: (2023)

Caveolin-1 Expression Increases upon Maturation in Dendritic Cells and Promotes Their Migration to Lymph Nodes Thereby Favoring the Induction of CD8(+) T Cell Responses
por: Oyarce, Cesar, et al.
Publicado: (2017)

Ectonucleotidase CD38 Demarcates Regulatory, Memory-Like CD8(+) T Cells with IFN-γ-Mediated Suppressor Activities
por: Bahri, Rajia, et al.
Publicado: (2012)

CD73‐generated extracellular adenosine promotes resolution of neutrophil‐mediated tissue injury and restrains metaplasia in pancreatitis
por: O'Brien, Baylee J., et al.
Publicado: (2022)

Host surface ectonucleotidase-CD73 and the opportunistic pathogen, Porphyromonas gingivalis, cross-modulation underlies a new homeostatic mechanism for chronic bacterial survival in human epithelial cells
por: Lee, Jaden S., et al.
Publicado: (2020)

Ectonucleotidases in Cancer and Inflammation
por: Stagg, John, et al.
Publicado: (2012)

T Lymphocyte Inhibition by Tumor-Infiltrating Dendritic Cells Involves Ectonucleotidase CD39 but Not Arginase-1
por: Trad, Malika, et al.
Publicado: (2015)

Vitamin A Impairs the Reprogramming of Tregs into IL-17-Producing Cells during Intestinal Inflammation
por: Tejón, Gabriela, et al.
Publicado: (2015)

The ectonucleotidase ENTPD1/CD39 limits biliary injury and fibrosis in mouse models of sclerosing cholangitis
por: Peng, Zhen‐Wei, et al.
Publicado: (2017)

Protein kinase inhibitor ceritinib blocks ectonucleotidase CD39 – a promising target for cancer immunotherapy
por: Schäkel, Laura, et al.
Publicado: (2022)

The Roles of CD73 in Cancer
por: Gao, Zhao-wei, et al.
Publicado: (2014)

Ectonucleotidases in Intestinal and Hepatic Inflammation
por: Vuerich, Marta, et al.
Publicado: (2019)

Ectonucleotidases in Acute and Chronic Inflammation
por: Giuliani, Anna Lisa, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_bo9f026frc1gj0h1n80tq7umac