Multiple Myeloma Cells Alter Adipogenesis, Increase Senescence-Related and Inflammatory Gene Transcript Expression, and Alter Metabolism in Preadipocytes

Within the bone marrow microenvironment, mesenchymal stromal cells (MSCs) are an essential precursor to bone marrow adipocytes and osteoblasts. The balance between this progenitor pool and mature cells (adipocytes and osteoblasts) is often skewed by disease and aging. In multiple myeloma (MM), a can...

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Detalles Bibliográficos
Autores principales: Fairfield, Heather, Costa, Samantha, Falank, Carolyne, Farrell, Mariah, Murphy, Connor S., D’Amico, Anastasia, Driscoll, Heather, Reagan, Michaela R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930573/
https://www.ncbi.nlm.nih.gov/pubmed/33680918
http://dx.doi.org/10.3389/fonc.2020.584683

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