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Viroporins vs. Other Pore-Forming Proteins: What Lessons Can We Take?
Pore-forming proteins (PFPs) exist in virtually all domains of life, and by disrupting cellular membranes, depending on the pore size, they cause ion dis-balance, small substances, or even protein efflux/influx, influencing cell’s signaling routes and fate. Such pore-forming proteins exist from bact...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930612/ https://www.ncbi.nlm.nih.gov/pubmed/33681145 http://dx.doi.org/10.3389/fchem.2021.626059 |
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author | Žerovnik, Eva |
author_facet | Žerovnik, Eva |
author_sort | Žerovnik, Eva |
collection | PubMed |
description | Pore-forming proteins (PFPs) exist in virtually all domains of life, and by disrupting cellular membranes, depending on the pore size, they cause ion dis-balance, small substances, or even protein efflux/influx, influencing cell’s signaling routes and fate. Such pore-forming proteins exist from bacteria to viruses and also shape host defense systems, including innate immunity. There is strong evidence that amyloid toxicity is also caused by prefibrillar oligomers making “amyloid pores” into cellular membranes. For most of the PFPs, a 2-step mechanism of protein-membrane interaction takes place on the “lipid rafts,” membrane microdomains rich in gangliosides and cholesterol. In this mini-review paper, common traits of different PFPs are looked at. Possible ways for therapy of channelopathies and/or modulating immunity relevant to the new threat of SARS-CoV-2 infections could be learnt from such comparisons. |
format | Online Article Text |
id | pubmed-7930612 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79306122021-03-05 Viroporins vs. Other Pore-Forming Proteins: What Lessons Can We Take? Žerovnik, Eva Front Chem Chemistry Pore-forming proteins (PFPs) exist in virtually all domains of life, and by disrupting cellular membranes, depending on the pore size, they cause ion dis-balance, small substances, or even protein efflux/influx, influencing cell’s signaling routes and fate. Such pore-forming proteins exist from bacteria to viruses and also shape host defense systems, including innate immunity. There is strong evidence that amyloid toxicity is also caused by prefibrillar oligomers making “amyloid pores” into cellular membranes. For most of the PFPs, a 2-step mechanism of protein-membrane interaction takes place on the “lipid rafts,” membrane microdomains rich in gangliosides and cholesterol. In this mini-review paper, common traits of different PFPs are looked at. Possible ways for therapy of channelopathies and/or modulating immunity relevant to the new threat of SARS-CoV-2 infections could be learnt from such comparisons. Frontiers Media S.A. 2021-02-18 /pmc/articles/PMC7930612/ /pubmed/33681145 http://dx.doi.org/10.3389/fchem.2021.626059 Text en Copyright © 2021 Žerovnik. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Chemistry Žerovnik, Eva Viroporins vs. Other Pore-Forming Proteins: What Lessons Can We Take? |
title | Viroporins vs. Other Pore-Forming Proteins: What Lessons Can We Take? |
title_full | Viroporins vs. Other Pore-Forming Proteins: What Lessons Can We Take? |
title_fullStr | Viroporins vs. Other Pore-Forming Proteins: What Lessons Can We Take? |
title_full_unstemmed | Viroporins vs. Other Pore-Forming Proteins: What Lessons Can We Take? |
title_short | Viroporins vs. Other Pore-Forming Proteins: What Lessons Can We Take? |
title_sort | viroporins vs. other pore-forming proteins: what lessons can we take? |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930612/ https://www.ncbi.nlm.nih.gov/pubmed/33681145 http://dx.doi.org/10.3389/fchem.2021.626059 |
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