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Circular RNAs Sparkle in the Diagnosis and Theranostics of Hepatocellular Carcinoma
Exonic circular RNAs (circRNAs) are a novel subgroup of non-coding RNAs, which are generated by a back-splicing mechanism of the exons or introns. Unlike the linear RNA, circRNA forms a covalently closed loop, and it normally appears more abundant than the linear products of its host gene. Due to th...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930616/ https://www.ncbi.nlm.nih.gov/pubmed/33679871 http://dx.doi.org/10.3389/fgene.2020.628655 |
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author | Wang, Menglan Wu, Minjie Xie, Tian Chen, Jianxiang |
author_facet | Wang, Menglan Wu, Minjie Xie, Tian Chen, Jianxiang |
author_sort | Wang, Menglan |
collection | PubMed |
description | Exonic circular RNAs (circRNAs) are a novel subgroup of non-coding RNAs, which are generated by a back-splicing mechanism of the exons or introns. Unlike the linear RNA, circRNA forms a covalently closed loop, and it normally appears more abundant than the linear products of its host gene. Due to the relatively high specificity and stability of circular RNAs in tissues and body fluid, circular RNAs have attracted widely scientific interest for its potential application in cancer diagnosis and as a guide for preclinical therapy, especially for hard-to-treat cancers with high heterogeneity, such as hepatocellular carcinoma (HCC). Thus, we summarize the updated knowledge of circular RNAs, including the mechanism of the generation of endogenous circular RNAs and their regulatory, diagnostic, and therapeutic roles in HCC. |
format | Online Article Text |
id | pubmed-7930616 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79306162021-03-05 Circular RNAs Sparkle in the Diagnosis and Theranostics of Hepatocellular Carcinoma Wang, Menglan Wu, Minjie Xie, Tian Chen, Jianxiang Front Genet Genetics Exonic circular RNAs (circRNAs) are a novel subgroup of non-coding RNAs, which are generated by a back-splicing mechanism of the exons or introns. Unlike the linear RNA, circRNA forms a covalently closed loop, and it normally appears more abundant than the linear products of its host gene. Due to the relatively high specificity and stability of circular RNAs in tissues and body fluid, circular RNAs have attracted widely scientific interest for its potential application in cancer diagnosis and as a guide for preclinical therapy, especially for hard-to-treat cancers with high heterogeneity, such as hepatocellular carcinoma (HCC). Thus, we summarize the updated knowledge of circular RNAs, including the mechanism of the generation of endogenous circular RNAs and their regulatory, diagnostic, and therapeutic roles in HCC. Frontiers Media S.A. 2021-02-18 /pmc/articles/PMC7930616/ /pubmed/33679871 http://dx.doi.org/10.3389/fgene.2020.628655 Text en Copyright © 2021 Wang, Wu, Xie and Chen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Wang, Menglan Wu, Minjie Xie, Tian Chen, Jianxiang Circular RNAs Sparkle in the Diagnosis and Theranostics of Hepatocellular Carcinoma |
title | Circular RNAs Sparkle in the Diagnosis and Theranostics of Hepatocellular Carcinoma |
title_full | Circular RNAs Sparkle in the Diagnosis and Theranostics of Hepatocellular Carcinoma |
title_fullStr | Circular RNAs Sparkle in the Diagnosis and Theranostics of Hepatocellular Carcinoma |
title_full_unstemmed | Circular RNAs Sparkle in the Diagnosis and Theranostics of Hepatocellular Carcinoma |
title_short | Circular RNAs Sparkle in the Diagnosis and Theranostics of Hepatocellular Carcinoma |
title_sort | circular rnas sparkle in the diagnosis and theranostics of hepatocellular carcinoma |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930616/ https://www.ncbi.nlm.nih.gov/pubmed/33679871 http://dx.doi.org/10.3389/fgene.2020.628655 |
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