Cargando…
A rare cause of acute liver failure due to haemophagocytic lymphohistiocytosis secondary to diffuse large B-cell lymphoma
Acute liver failure is a life-threatening condition commonly caused by drug-induced hepatotoxicity or viral hepatitides. However, there are a number of rarer causes such as haemophagocytic lymphohistiocytosis. Haemophagocytic lymphohistiocytosis is a syndrome of uncontrolled immune cell activation,...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930656/ https://www.ncbi.nlm.nih.gov/pubmed/33717491 http://dx.doi.org/10.1177/2054270420983623 |
_version_ | 1783660141965475840 |
---|---|
author | Coppola, Andrew Chey, Chia O’Donovan, Emma Rahman, Monira |
author_facet | Coppola, Andrew Chey, Chia O’Donovan, Emma Rahman, Monira |
author_sort | Coppola, Andrew |
collection | PubMed |
description | Acute liver failure is a life-threatening condition commonly caused by drug-induced hepatotoxicity or viral hepatitides. However, there are a number of rarer causes such as haemophagocytic lymphohistiocytosis. Haemophagocytic lymphohistiocytosis is a syndrome of uncontrolled immune cell activation, triggered by infection or malignancy, which carries a high mortality. Whilst mild to moderate liver injury is commonly seen with haemophagocytic lymphohistiocytosis, acute liver failure has rarely been reported in adults. We present a case of a 74-year-old man with acute liver failure secondary to haemophagocytic lymphohistiocytosis triggered by undiagnosed large B-cell lymphoma. Initially treated for biliary sepsis, there was a delay in the diagnosis of haemophagocytic lymphohistiocytosis and despite initiating chemotherapy, he died soon after. This case highlights the importance of considering haemophagocytic lymphohistiocytosis as a rare cause of acute liver failure, as given the life-threatening potential of haemophagocytic lymphohistiocytosis, a prompt diagnosis may allow early initiation of chemotherapy for any chance of survival. |
format | Online Article Text |
id | pubmed-7930656 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-79306562021-03-12 A rare cause of acute liver failure due to haemophagocytic lymphohistiocytosis secondary to diffuse large B-cell lymphoma Coppola, Andrew Chey, Chia O’Donovan, Emma Rahman, Monira JRSM Open Case Report Acute liver failure is a life-threatening condition commonly caused by drug-induced hepatotoxicity or viral hepatitides. However, there are a number of rarer causes such as haemophagocytic lymphohistiocytosis. Haemophagocytic lymphohistiocytosis is a syndrome of uncontrolled immune cell activation, triggered by infection or malignancy, which carries a high mortality. Whilst mild to moderate liver injury is commonly seen with haemophagocytic lymphohistiocytosis, acute liver failure has rarely been reported in adults. We present a case of a 74-year-old man with acute liver failure secondary to haemophagocytic lymphohistiocytosis triggered by undiagnosed large B-cell lymphoma. Initially treated for biliary sepsis, there was a delay in the diagnosis of haemophagocytic lymphohistiocytosis and despite initiating chemotherapy, he died soon after. This case highlights the importance of considering haemophagocytic lymphohistiocytosis as a rare cause of acute liver failure, as given the life-threatening potential of haemophagocytic lymphohistiocytosis, a prompt diagnosis may allow early initiation of chemotherapy for any chance of survival. SAGE Publications 2021-03-02 /pmc/articles/PMC7930656/ /pubmed/33717491 http://dx.doi.org/10.1177/2054270420983623 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Coppola, Andrew Chey, Chia O’Donovan, Emma Rahman, Monira A rare cause of acute liver failure due to haemophagocytic lymphohistiocytosis secondary to diffuse large B-cell lymphoma |
title | A rare cause of acute liver failure due to haemophagocytic lymphohistiocytosis secondary to diffuse large B-cell lymphoma |
title_full | A rare cause of acute liver failure due to haemophagocytic lymphohistiocytosis secondary to diffuse large B-cell lymphoma |
title_fullStr | A rare cause of acute liver failure due to haemophagocytic lymphohistiocytosis secondary to diffuse large B-cell lymphoma |
title_full_unstemmed | A rare cause of acute liver failure due to haemophagocytic lymphohistiocytosis secondary to diffuse large B-cell lymphoma |
title_short | A rare cause of acute liver failure due to haemophagocytic lymphohistiocytosis secondary to diffuse large B-cell lymphoma |
title_sort | rare cause of acute liver failure due to haemophagocytic lymphohistiocytosis secondary to diffuse large b-cell lymphoma |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930656/ https://www.ncbi.nlm.nih.gov/pubmed/33717491 http://dx.doi.org/10.1177/2054270420983623 |
work_keys_str_mv | AT coppolaandrew ararecauseofacuteliverfailureduetohaemophagocyticlymphohistiocytosissecondarytodiffuselargebcelllymphoma AT cheychia ararecauseofacuteliverfailureduetohaemophagocyticlymphohistiocytosissecondarytodiffuselargebcelllymphoma AT odonovanemma ararecauseofacuteliverfailureduetohaemophagocyticlymphohistiocytosissecondarytodiffuselargebcelllymphoma AT rahmanmonira ararecauseofacuteliverfailureduetohaemophagocyticlymphohistiocytosissecondarytodiffuselargebcelllymphoma AT coppolaandrew rarecauseofacuteliverfailureduetohaemophagocyticlymphohistiocytosissecondarytodiffuselargebcelllymphoma AT cheychia rarecauseofacuteliverfailureduetohaemophagocyticlymphohistiocytosissecondarytodiffuselargebcelllymphoma AT odonovanemma rarecauseofacuteliverfailureduetohaemophagocyticlymphohistiocytosissecondarytodiffuselargebcelllymphoma AT rahmanmonira rarecauseofacuteliverfailureduetohaemophagocyticlymphohistiocytosissecondarytodiffuselargebcelllymphoma |