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Modulation of hyaluronan synthases and involvement of T cell-derived hyaluronan in autoimmune responses to transplanted islets

The extracellular matrix glycosaminoglycan hyaluronan (HA) accumulates in human and mouse islets during the onset of autoimmune type 1 diabetes (T1D). HA plays a critical role in T1D pathogenesis, as spontaneous disease is blocked in mice fed the HA synthesis inhibitor 4-methylumbelliferone (4MU). T...

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Detalles Bibliográficos
Autores principales:	Gebe, John A., Gooden, Michel D., Workman, Gail, Nagy, Nadine, Bollyky, Paul L., Wight, Thomas N., Vernon, Robert B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930869/ https://www.ncbi.nlm.nih.gov/pubmed/33718858 http://dx.doi.org/10.1016/j.mbplus.2020.100052

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