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Infective Endocarditis by Yersinia Species: A Systematic Review

Yersinia spp. are non-spore-forming Gram-negative bacilli. They comprise only three species known to cause disease in humans, namely Y. pestis, Y. enterocolitica and Y. pseudotuberculosis. Since infective endocarditis (IE) is rarely caused by Yersinia, the management of these infections can be probl...

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Autores principales: Ioannou, Petros, Vougiouklakis, Georgios, Baliou, Stella, Miliara, Eugenia, Kofteridis, Diamantis P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931003/
https://www.ncbi.nlm.nih.gov/pubmed/33540800
http://dx.doi.org/10.3390/tropicalmed6010019
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author Ioannou, Petros
Vougiouklakis, Georgios
Baliou, Stella
Miliara, Eugenia
Kofteridis, Diamantis P.
author_facet Ioannou, Petros
Vougiouklakis, Georgios
Baliou, Stella
Miliara, Eugenia
Kofteridis, Diamantis P.
author_sort Ioannou, Petros
collection PubMed
description Yersinia spp. are non-spore-forming Gram-negative bacilli. They comprise only three species known to cause disease in humans, namely Y. pestis, Y. enterocolitica and Y. pseudotuberculosis. Since infective endocarditis (IE) is rarely caused by Yersinia, the management of these infections can be problematic due to the lack of experience. The purpose of this study was to systematically review all published cases of IE by Yersinia species in the literature. A systematic review of PubMed, Scopus and Cochrane Library (through 1 November 2020) for studies providing epidemiological, clinical and microbiological information as well as data on treatment and outcomes of IE caused by Yersinia species was performed. A total of 12 studies, containing data of 12 patients, were included. A prosthetic valve was present in 17% of patients. The mitral valve was the most commonly infected site, followed by the aortic valve. Fever, sepsis and embolic phenomena were common clinical signs, followed by heart failure. Aminoglycosides, cephalosporins and quinolones were the most commonly used antimicrobials. Clinical cure was noted in 83%, while overall mortality was 17%. This systematic review describes IE by Yersinia and provides information on patients’ epidemiology, clinical signs and the related therapeutic strategies and outcomes.
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spelling pubmed-79310032021-03-05 Infective Endocarditis by Yersinia Species: A Systematic Review Ioannou, Petros Vougiouklakis, Georgios Baliou, Stella Miliara, Eugenia Kofteridis, Diamantis P. Trop Med Infect Dis Review Yersinia spp. are non-spore-forming Gram-negative bacilli. They comprise only three species known to cause disease in humans, namely Y. pestis, Y. enterocolitica and Y. pseudotuberculosis. Since infective endocarditis (IE) is rarely caused by Yersinia, the management of these infections can be problematic due to the lack of experience. The purpose of this study was to systematically review all published cases of IE by Yersinia species in the literature. A systematic review of PubMed, Scopus and Cochrane Library (through 1 November 2020) for studies providing epidemiological, clinical and microbiological information as well as data on treatment and outcomes of IE caused by Yersinia species was performed. A total of 12 studies, containing data of 12 patients, were included. A prosthetic valve was present in 17% of patients. The mitral valve was the most commonly infected site, followed by the aortic valve. Fever, sepsis and embolic phenomena were common clinical signs, followed by heart failure. Aminoglycosides, cephalosporins and quinolones were the most commonly used antimicrobials. Clinical cure was noted in 83%, while overall mortality was 17%. This systematic review describes IE by Yersinia and provides information on patients’ epidemiology, clinical signs and the related therapeutic strategies and outcomes. MDPI 2021-02-02 /pmc/articles/PMC7931003/ /pubmed/33540800 http://dx.doi.org/10.3390/tropicalmed6010019 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ioannou, Petros
Vougiouklakis, Georgios
Baliou, Stella
Miliara, Eugenia
Kofteridis, Diamantis P.
Infective Endocarditis by Yersinia Species: A Systematic Review
title Infective Endocarditis by Yersinia Species: A Systematic Review
title_full Infective Endocarditis by Yersinia Species: A Systematic Review
title_fullStr Infective Endocarditis by Yersinia Species: A Systematic Review
title_full_unstemmed Infective Endocarditis by Yersinia Species: A Systematic Review
title_short Infective Endocarditis by Yersinia Species: A Systematic Review
title_sort infective endocarditis by yersinia species: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931003/
https://www.ncbi.nlm.nih.gov/pubmed/33540800
http://dx.doi.org/10.3390/tropicalmed6010019
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