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κ-opioid receptor agonist U50488H attenuates postoperative cognitive dysfunction of cardiopulmonary bypass rats through the PI3K/AKT/Nrf2/HO-1 pathway

Postoperative cognitive dysfunction (POCD) is a common complication following cardiopulmonary bypass (CPB). U50488H, a κ-opioid receptor (KOR) agonist, can specifically activate KORs on hippocampal nerve cells, resulting in neuroprotective effects. The present study established a CPB rat model, obse...

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Detalles Bibliográficos
Autores principales:	Fan, Jianing, Li, Long, Qu, Pengxia, Diao, Yugang, Sun, Yingjie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931006/ https://www.ncbi.nlm.nih.gov/pubmed/33649775 http://dx.doi.org/10.3892/mmr.2021.11933

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