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Acute Pancreatitis as a Complication of Antiepileptic Treatment: Case Series and Review of the Literature

Acute pancreatitis (AP) appears to be rare disease in childhood. In children, it has a different aetiology and course, and requires different management than in adult patients. The diagnosis of AP is based on at least two of the three criteria, which include typical clinical symptoms, abnormalities...

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Autores principales: Pawłowska-Kamieniak, Agnieszka, Krawiec, Paulina, Pac-Kożuchowska, Elżbieta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931036/
https://www.ncbi.nlm.nih.gov/pubmed/33652736
http://dx.doi.org/10.3390/pediatric13010014
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author Pawłowska-Kamieniak, Agnieszka
Krawiec, Paulina
Pac-Kożuchowska, Elżbieta
author_facet Pawłowska-Kamieniak, Agnieszka
Krawiec, Paulina
Pac-Kożuchowska, Elżbieta
author_sort Pawłowska-Kamieniak, Agnieszka
collection PubMed
description Acute pancreatitis (AP) appears to be rare disease in childhood. In children, it has a different aetiology and course, and requires different management than in adult patients. The diagnosis of AP is based on at least two of the three criteria, which include typical clinical symptoms, abnormalities in laboratory tests and/or imaging studies of the pancreas. There are many known causes leading to AP in children including infections, blunt abdominal trauma, genetic factors, gallstone disease, metabolic disorders, anatomical defects of the pancreas, systemic diseases, as well as drugs, including antiepileptic drugs, and especially preparations of valproic acid. In our study, we present four cases of young patients diagnosed with acute pancreatitis as a complication of valproic acid therapy and we present a review of the literature. We believe that the activity of pancreatic enzymes should be monitored in children treated with valproate preparations in the case of clinical symptoms suggesting AP.
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spelling pubmed-79310362021-03-05 Acute Pancreatitis as a Complication of Antiepileptic Treatment: Case Series and Review of the Literature Pawłowska-Kamieniak, Agnieszka Krawiec, Paulina Pac-Kożuchowska, Elżbieta Pediatr Rep Article Acute pancreatitis (AP) appears to be rare disease in childhood. In children, it has a different aetiology and course, and requires different management than in adult patients. The diagnosis of AP is based on at least two of the three criteria, which include typical clinical symptoms, abnormalities in laboratory tests and/or imaging studies of the pancreas. There are many known causes leading to AP in children including infections, blunt abdominal trauma, genetic factors, gallstone disease, metabolic disorders, anatomical defects of the pancreas, systemic diseases, as well as drugs, including antiepileptic drugs, and especially preparations of valproic acid. In our study, we present four cases of young patients diagnosed with acute pancreatitis as a complication of valproic acid therapy and we present a review of the literature. We believe that the activity of pancreatic enzymes should be monitored in children treated with valproate preparations in the case of clinical symptoms suggesting AP. MDPI 2021-02-26 /pmc/articles/PMC7931036/ /pubmed/33652736 http://dx.doi.org/10.3390/pediatric13010014 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pawłowska-Kamieniak, Agnieszka
Krawiec, Paulina
Pac-Kożuchowska, Elżbieta
Acute Pancreatitis as a Complication of Antiepileptic Treatment: Case Series and Review of the Literature
title Acute Pancreatitis as a Complication of Antiepileptic Treatment: Case Series and Review of the Literature
title_full Acute Pancreatitis as a Complication of Antiepileptic Treatment: Case Series and Review of the Literature
title_fullStr Acute Pancreatitis as a Complication of Antiepileptic Treatment: Case Series and Review of the Literature
title_full_unstemmed Acute Pancreatitis as a Complication of Antiepileptic Treatment: Case Series and Review of the Literature
title_short Acute Pancreatitis as a Complication of Antiepileptic Treatment: Case Series and Review of the Literature
title_sort acute pancreatitis as a complication of antiepileptic treatment: case series and review of the literature
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931036/
https://www.ncbi.nlm.nih.gov/pubmed/33652736
http://dx.doi.org/10.3390/pediatric13010014
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