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Acute Pancreatitis as a Complication of Antiepileptic Treatment: Case Series and Review of the Literature
Acute pancreatitis (AP) appears to be rare disease in childhood. In children, it has a different aetiology and course, and requires different management than in adult patients. The diagnosis of AP is based on at least two of the three criteria, which include typical clinical symptoms, abnormalities...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931036/ https://www.ncbi.nlm.nih.gov/pubmed/33652736 http://dx.doi.org/10.3390/pediatric13010014 |
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author | Pawłowska-Kamieniak, Agnieszka Krawiec, Paulina Pac-Kożuchowska, Elżbieta |
author_facet | Pawłowska-Kamieniak, Agnieszka Krawiec, Paulina Pac-Kożuchowska, Elżbieta |
author_sort | Pawłowska-Kamieniak, Agnieszka |
collection | PubMed |
description | Acute pancreatitis (AP) appears to be rare disease in childhood. In children, it has a different aetiology and course, and requires different management than in adult patients. The diagnosis of AP is based on at least two of the three criteria, which include typical clinical symptoms, abnormalities in laboratory tests and/or imaging studies of the pancreas. There are many known causes leading to AP in children including infections, blunt abdominal trauma, genetic factors, gallstone disease, metabolic disorders, anatomical defects of the pancreas, systemic diseases, as well as drugs, including antiepileptic drugs, and especially preparations of valproic acid. In our study, we present four cases of young patients diagnosed with acute pancreatitis as a complication of valproic acid therapy and we present a review of the literature. We believe that the activity of pancreatic enzymes should be monitored in children treated with valproate preparations in the case of clinical symptoms suggesting AP. |
format | Online Article Text |
id | pubmed-7931036 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79310362021-03-05 Acute Pancreatitis as a Complication of Antiepileptic Treatment: Case Series and Review of the Literature Pawłowska-Kamieniak, Agnieszka Krawiec, Paulina Pac-Kożuchowska, Elżbieta Pediatr Rep Article Acute pancreatitis (AP) appears to be rare disease in childhood. In children, it has a different aetiology and course, and requires different management than in adult patients. The diagnosis of AP is based on at least two of the three criteria, which include typical clinical symptoms, abnormalities in laboratory tests and/or imaging studies of the pancreas. There are many known causes leading to AP in children including infections, blunt abdominal trauma, genetic factors, gallstone disease, metabolic disorders, anatomical defects of the pancreas, systemic diseases, as well as drugs, including antiepileptic drugs, and especially preparations of valproic acid. In our study, we present four cases of young patients diagnosed with acute pancreatitis as a complication of valproic acid therapy and we present a review of the literature. We believe that the activity of pancreatic enzymes should be monitored in children treated with valproate preparations in the case of clinical symptoms suggesting AP. MDPI 2021-02-26 /pmc/articles/PMC7931036/ /pubmed/33652736 http://dx.doi.org/10.3390/pediatric13010014 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pawłowska-Kamieniak, Agnieszka Krawiec, Paulina Pac-Kożuchowska, Elżbieta Acute Pancreatitis as a Complication of Antiepileptic Treatment: Case Series and Review of the Literature |
title | Acute Pancreatitis as a Complication of Antiepileptic Treatment: Case Series and Review of the Literature |
title_full | Acute Pancreatitis as a Complication of Antiepileptic Treatment: Case Series and Review of the Literature |
title_fullStr | Acute Pancreatitis as a Complication of Antiepileptic Treatment: Case Series and Review of the Literature |
title_full_unstemmed | Acute Pancreatitis as a Complication of Antiepileptic Treatment: Case Series and Review of the Literature |
title_short | Acute Pancreatitis as a Complication of Antiepileptic Treatment: Case Series and Review of the Literature |
title_sort | acute pancreatitis as a complication of antiepileptic treatment: case series and review of the literature |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931036/ https://www.ncbi.nlm.nih.gov/pubmed/33652736 http://dx.doi.org/10.3390/pediatric13010014 |
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