Cargando…

The Dystrophin Node as Integrator of Cytoskeletal Organization, Lateral Force Transmission, Fiber Stability and Cellular Signaling in Skeletal Muscle

The systematic bioanalytical characterization of the protein product of the DMD gene, which is defective in the pediatric disorder Duchenne muscular dystrophy, led to the discovery of the membrane cytoskeletal protein dystrophin. Its full-length muscle isoform Dp427-M is tightly linked to a sarcolem...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dowling, Paul, Gargan, Stephen, Murphy, Sandra, Zweyer, Margit, Sabir, Hemmen, Swandulla, Dieter, Ohlendieck, Kay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931087/ https://www.ncbi.nlm.nih.gov/pubmed/33540575 http://dx.doi.org/10.3390/proteomes9010009

Ejemplares similares

Proteome-wide Changes in the mdx-4cv Spleen due to Pathophysiological Cross Talk with Dystrophin-Deficient Skeletal Muscle
por: Dowling, Paul, et al.
Publicado: (2020)

Chemical crosslinking analysis of β-dystroglycan in dystrophin-deficient skeletal muscle
por: Murphy, Sandra, et al.
Publicado: (2018)

Proteomic profiling of the interface between the stomach wall and the pancreas in dystrophinopathy
por: Dowling, Paul, et al.
Publicado: (2021)

Extracellular Matrix Proteomics: The mdx-4cv Mouse Diaphragm as a Surrogate for Studying Myofibrosis in Dystrophinopathy
por: Dowling, Paul, et al.
Publicado: (2023)

Characterization of Contractile Proteins from Skeletal Muscle Using Gel-Based Top-Down Proteomics
por: Dowling, Paul, et al.
Publicado: (2019)

Mass spectrometry-based proteomic characterization of the middle-aged mouse brain for animal model research of neuromuscular diseases
por: Dowling, Paul, et al.
Publicado: (2023)

Dowling, P.; et al. Characterization of Contractile Proteins from Skeletal Muscle Using Gel-Based Top-Down Proteomics. Proteomes 2019, 7, 25
por: Dowling, Paul, et al.
Publicado: (2019)

Fiber-Type Shifting in Sarcopenia of Old Age: Proteomic Profiling of the Contractile Apparatus of Skeletal Muscles
por: Dowling, Paul, et al.
Publicado: (2023)

Concurrent Label-Free Mass Spectrometric Analysis of Dystrophin Isoform Dp427 and the Myofibrosis Marker Collagen in Crude Extracts from mdx-4cv Skeletal Muscles
por: Murphy, Sandra, et al.
Publicado: (2015)

Protocol for the Bottom-Up Proteomic Analysis of Mouse Spleen
por: Dowling, Paul, et al.
Publicado: (2020)

Proteomic Identification of Markers of Membrane Repair, Regeneration and Fibrosis in the Aged and Dystrophic Diaphragm
por: Gargan, Stephen, et al.
Publicado: (2022)

Simultaneous Pathoproteomic Evaluation of the Dystrophin-Glycoprotein Complex and Secondary Changes in the mdx-4cv Mouse Model of Duchenne Muscular Dystrophy
por: Murphy, Sandra, et al.
Publicado: (2015)

Comparative gel‐based proteomic analysis of chemically crosslinked complexes in dystrophic skeletal muscle
por: Murphy, Sandra, et al.
Publicado: (2018)

Mass spectrometry-based proteomic analysis of middle-aged vs. aged vastus lateralis reveals increased levels of carbonic anhydrase isoform 3 in senescent human skeletal muscle
por: STAUNTON, LISA, et al.
Publicado: (2012)

Mass Spectrometric Profiling of Extraocular Muscle and Proteomic Adaptations in the mdx-4cv Model of Duchenne Muscular Dystrophy
por: Gargan, Stephen, et al.
Publicado: (2021)

Subproteomic profiling of sarcolemma from dystrophic mdx-4cv skeletal muscle
por: Murphy, Sandra, et al.
Publicado: (2018)

Proteomics reveals drastic increase of extracellular matrix proteins collagen and dermatopontin in the aged mdx diaphragm model of Duchenne muscular dystrophy
por: CARBERRY, STEVEN, et al.
Publicado: (2012)

Profiling of Age-Related Changes in the Tibialis Anterior Muscle Proteome of the mdx Mouse Model of Dystrophinopathy
por: Carberry, Steven, et al.
Publicado: (2012)

Application of Fluorescence Two-Dimensional Difference In-Gel Electrophoresis as a Proteomic Biomarker Discovery Tool in Muscular Dystrophy Research
por: Carberry, Steven, et al.
Publicado: (2013)

Dataset on the comparative proteomic profiling of mouse saliva and serum from wild type versus the dystrophic mdx-4cv mouse model of dystrophinopathy
por: Murphy, Sandra, et al.
Publicado: (2018)

Proteomic identification of elevated saliva kallikrein levels in the mdx-4cv mouse model of Duchenne muscular dystrophy
por: Murphy, Sandra, et al.
Publicado: (2018)

Proteomic profiling of impaired excitation–contraction coupling and abnormal calcium handling in muscular dystrophy
por: Dowling, Paul, et al.
Publicado: (2022)

Dataset on the mass spectrometry-based proteomic profiling of the kidney from wild type and the dystrophic mdx-4cv mouse model of X-linked muscular dystrophy
por: Dowling, Paul, et al.
Publicado: (2020)

Proteomic profiling of mdx-4cv serum reveals highly elevated levels of the inflammation-induced plasma marker haptoglobin in muscular dystrophy
por: Murphy, Sandra, et al.
Publicado: (2017)

Mass Spectrometry-Based Proteomic Technology and Its Application to Study Skeletal Muscle Cell Biology
por: Dowling, Paul, et al.
Publicado: (2023)

Label-free mass spectrometric analysis reveals complex changes in the brain proteome from the mdx-4cv mouse model of Duchenne muscular dystrophy
por: Murphy, Sandra, et al.
Publicado: (2015)

Proteomic profiling of liver tissue from the mdx-4cv mouse model of Duchenne muscular dystrophy
por: Murphy, Sandra, et al.
Publicado: (2018)

The biochemical and mass spectrometric profiling of the dystrophin complexome from skeletal muscle
por: Murphy, Sandra, et al.
Publicado: (2015)

Complexity of skeletal muscle degeneration: multi-systems pathophysiology and organ crosstalk in dystrophinopathy
por: Ohlendieck, Kay, et al.
Publicado: (2021)

Proteomic profiling of the brain from the wobbler mouse model of amyotrophic lateral sclerosis reveals elevated levels of the astrogliosis marker glial fibrillary acidic protein
por: Murphy, Sandra, et al.
Publicado: (2023)

Diversity of the Brain Dystrophin-Glycoprotein Complex
por: Culligan, Kevin, et al.
Publicado: (2002)

Comparative Skeletal Muscle Proteomics Using Two-Dimensional Gel Electrophoresis
por: Murphy, Sandra, et al.
Publicado: (2016)

Mass spectrometric identification of dystrophin, the protein product of the Duchenne muscular dystrophy gene, in distinct muscle surface membranes
por: Murphy, Sandra, et al.
Publicado: (2017)

Neutrophil Extracellular Traps Release following Hypoxic-Ischemic Brain Injury in Newborn Rats Treated with Therapeutic Hypothermia
por: Bernis, Maria E., et al.
Publicado: (2023)

Brain dystrophin-glycoprotein complex: Persistent expression of beta-dystroglycan, impaired oligomerization of Dp71 and up-regulation of utrophins in animal models of muscular dystrophy
por: Culligan, Kevin, et al.
Publicado: (2001)

Proteomic Profiling of the Dystrophin-Deficient mdx Phenocopy of Dystrophinopathy-Associated Cardiomyopathy
por: Holland, Ashling, et al.
Publicado: (2014)

Deficiency in Cardiac Dystrophin Affects the Abundance of the α-/β-Dystroglycan Complex
por: Lohan, James, et al.
Publicado: (2005)

Direct visualization of the dystrophin network on skeletal muscle fiber membrane
Publicado: (1992)

Impact of Hypoxia-Ischemia on Neurogenesis and Structural and Functional Outcomes in a Mild–Moderate Neonatal Hypoxia-Ischemia Brain Injury Model
por: Ehlting, Anne, et al.
Publicado: (2022)

Temporal Characterization of Microglia-Associated Pro- and Anti-Inflammatory Genes in a Neonatal Inflammation-Sensitized Hypoxic-Ischemic Brain Injury Model
por: Bernis, Maria E., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_27mp0sv8cmet7hpm6p17ed3rc1