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Microneedle for transdermal drug delivery: current trends and fabrication
BACKGROUND: Transdermal delivery has the advantage of bypassing the first-pass effect and allowing sustained release of the drug. However, the drug delivery is limited owing to the barrier created by the stratum corneum. Microneedles are a transdermal drug delivery system that is painless, less inva...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Singapore
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931162/ https://www.ncbi.nlm.nih.gov/pubmed/33686358 http://dx.doi.org/10.1007/s40005-021-00512-4 |
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author | Jung, Jae Hwan Jin, Sung Giu |
author_facet | Jung, Jae Hwan Jin, Sung Giu |
author_sort | Jung, Jae Hwan |
collection | PubMed |
description | BACKGROUND: Transdermal delivery has the advantage of bypassing the first-pass effect and allowing sustained release of the drug. However, the drug delivery is limited owing to the barrier created by the stratum corneum. Microneedles are a transdermal drug delivery system that is painless, less invasive, and easy to self-administer, with a high drug bioavailability. AREA COVERED: The dose, delivery rate, and efficacy of the drugs can be controlled by the microneedle design and drug formulations. This review introduces the types of microneedles and their design, materials used for fabrication, and manufacturing methods. Additionally, recent biological applications and clinical trials are introduced. EXPERT OPINION: With advancements made in formulation technologies, the drug-loading capability of microneedles can be improved. 3D printing and digital technology contribute to the improvement of microneedle fabrication technology. However, regulations regarding the manufacture of microneedle products should be established as soon as possible to promote commercialization. |
format | Online Article Text |
id | pubmed-7931162 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-79311622021-03-04 Microneedle for transdermal drug delivery: current trends and fabrication Jung, Jae Hwan Jin, Sung Giu J Pharm Investig Review BACKGROUND: Transdermal delivery has the advantage of bypassing the first-pass effect and allowing sustained release of the drug. However, the drug delivery is limited owing to the barrier created by the stratum corneum. Microneedles are a transdermal drug delivery system that is painless, less invasive, and easy to self-administer, with a high drug bioavailability. AREA COVERED: The dose, delivery rate, and efficacy of the drugs can be controlled by the microneedle design and drug formulations. This review introduces the types of microneedles and their design, materials used for fabrication, and manufacturing methods. Additionally, recent biological applications and clinical trials are introduced. EXPERT OPINION: With advancements made in formulation technologies, the drug-loading capability of microneedles can be improved. 3D printing and digital technology contribute to the improvement of microneedle fabrication technology. However, regulations regarding the manufacture of microneedle products should be established as soon as possible to promote commercialization. Springer Singapore 2021-03-04 2021 /pmc/articles/PMC7931162/ /pubmed/33686358 http://dx.doi.org/10.1007/s40005-021-00512-4 Text en © The Korean Society of Pharmaceutical Sciences and Technology 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Jung, Jae Hwan Jin, Sung Giu Microneedle for transdermal drug delivery: current trends and fabrication |
title | Microneedle for transdermal drug delivery: current trends and fabrication |
title_full | Microneedle for transdermal drug delivery: current trends and fabrication |
title_fullStr | Microneedle for transdermal drug delivery: current trends and fabrication |
title_full_unstemmed | Microneedle for transdermal drug delivery: current trends and fabrication |
title_short | Microneedle for transdermal drug delivery: current trends and fabrication |
title_sort | microneedle for transdermal drug delivery: current trends and fabrication |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931162/ https://www.ncbi.nlm.nih.gov/pubmed/33686358 http://dx.doi.org/10.1007/s40005-021-00512-4 |
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