External limiting membrane: retinal structural barrier in diabetic macular edema

Advances in spectral-domain optical coherence tomography (SD-OCT) technology have enhanced the understanding of external limiting membrane (ELM) and ellipsoid zone (EZ) in diabetic macular edema. An increase in VEGF has been demonstrated to be associated with sequential ELM and EZ disruption on SD-O...

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Autores principales: Saxena, Sandeep, Akduman, Levent, Meyer, Carsten H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931353/
https://www.ncbi.nlm.nih.gov/pubmed/33663592
http://dx.doi.org/10.1186/s40942-021-00284-x
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author Saxena, Sandeep
Akduman, Levent
Meyer, Carsten H.
author_facet Saxena, Sandeep
Akduman, Levent
Meyer, Carsten H.
author_sort Saxena, Sandeep
collection PubMed
description Advances in spectral-domain optical coherence tomography (SD-OCT) technology have enhanced the understanding of external limiting membrane (ELM) and ellipsoid zone (EZ) in diabetic macular edema. An increase in VEGF has been demonstrated to be associated with sequential ELM and EZ disruption on SD-OCT. An intact ELM is a prerequisite for an intact EZ in DME. Anti-VEGF therapy leads to restoration of barrier effect of ELM. The ELM restores first followed by EZ restoration.
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spelling pubmed-79313532021-03-05 External limiting membrane: retinal structural barrier in diabetic macular edema Saxena, Sandeep Akduman, Levent Meyer, Carsten H. Int J Retina Vitreous Commentary Advances in spectral-domain optical coherence tomography (SD-OCT) technology have enhanced the understanding of external limiting membrane (ELM) and ellipsoid zone (EZ) in diabetic macular edema. An increase in VEGF has been demonstrated to be associated with sequential ELM and EZ disruption on SD-OCT. An intact ELM is a prerequisite for an intact EZ in DME. Anti-VEGF therapy leads to restoration of barrier effect of ELM. The ELM restores first followed by EZ restoration. BioMed Central 2021-03-04 /pmc/articles/PMC7931353/ /pubmed/33663592 http://dx.doi.org/10.1186/s40942-021-00284-x Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Commentary
Saxena, Sandeep
Akduman, Levent
Meyer, Carsten H.
External limiting membrane: retinal structural barrier in diabetic macular edema
title External limiting membrane: retinal structural barrier in diabetic macular edema
title_full External limiting membrane: retinal structural barrier in diabetic macular edema
title_fullStr External limiting membrane: retinal structural barrier in diabetic macular edema
title_full_unstemmed External limiting membrane: retinal structural barrier in diabetic macular edema
title_short External limiting membrane: retinal structural barrier in diabetic macular edema
title_sort external limiting membrane: retinal structural barrier in diabetic macular edema
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931353/
https://www.ncbi.nlm.nih.gov/pubmed/33663592
http://dx.doi.org/10.1186/s40942-021-00284-x
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