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Self-Balance of Intestinal Flora in Spouses of Patients With Rheumatoid Arthritis

We sought to characterize and assess differences in compositions of intestinal flora between patients with rheumatoid arthritis (RA) and their respective spouses. Eighty volunteers were recruited, including 30 pairs of RA patients and their spouses, and 20 healthy individuals. Fresh stool samples we...

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Autores principales: Liu, Zhihui, Wu, Yuxi, Luo, Yubin, Wei, Shixiong, Lu, Chenyang, Zhou, Yi, Wang, Jing, Miao, Ting, Lin, Hui, Zhao, Yi, Liu, Qi, Liu, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931358/
https://www.ncbi.nlm.nih.gov/pubmed/33681234
http://dx.doi.org/10.3389/fmed.2020.00538
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author Liu, Zhihui
Wu, Yuxi
Luo, Yubin
Wei, Shixiong
Lu, Chenyang
Zhou, Yi
Wang, Jing
Miao, Ting
Lin, Hui
Zhao, Yi
Liu, Qi
Liu, Yi
author_facet Liu, Zhihui
Wu, Yuxi
Luo, Yubin
Wei, Shixiong
Lu, Chenyang
Zhou, Yi
Wang, Jing
Miao, Ting
Lin, Hui
Zhao, Yi
Liu, Qi
Liu, Yi
author_sort Liu, Zhihui
collection PubMed
description We sought to characterize and assess differences in compositions of intestinal flora between patients with rheumatoid arthritis (RA) and their respective spouses. Eighty volunteers were recruited, including 30 pairs of RA patients and their spouses, and 20 healthy individuals. Fresh stool samples were collected, processed, and 16S rRNA-sequencing was performed. Data were analyzed using an operational taxonomic units-based method, and community structure assessments were performed. Community composition analysis indicated that there were similar intestinal microbiota structures in RA and in their respective spouses. Gut microbiota in spouses of RA were different from those of the healthy controls group, but these differences were not significant. We found that Blautia spp. and Streptococcus spp. were two most associated species in RA and these taxa were significantly higher in comparison to healthy controls. In contrast, our findings suggested that Roseburia spp. and Lachnoclostridium spp. were significantly lower in the RA in comparison to healthy controls. In conclusion, RA patients shared similar gut microbiota pattern with their spouses which were different from healthy individuals. The findings suggest that disturbance of the balance of gut microbiota may play an important role in the dynamics of pathogenesis of RA.
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spelling pubmed-79313582021-03-05 Self-Balance of Intestinal Flora in Spouses of Patients With Rheumatoid Arthritis Liu, Zhihui Wu, Yuxi Luo, Yubin Wei, Shixiong Lu, Chenyang Zhou, Yi Wang, Jing Miao, Ting Lin, Hui Zhao, Yi Liu, Qi Liu, Yi Front Med (Lausanne) Medicine We sought to characterize and assess differences in compositions of intestinal flora between patients with rheumatoid arthritis (RA) and their respective spouses. Eighty volunteers were recruited, including 30 pairs of RA patients and their spouses, and 20 healthy individuals. Fresh stool samples were collected, processed, and 16S rRNA-sequencing was performed. Data were analyzed using an operational taxonomic units-based method, and community structure assessments were performed. Community composition analysis indicated that there were similar intestinal microbiota structures in RA and in their respective spouses. Gut microbiota in spouses of RA were different from those of the healthy controls group, but these differences were not significant. We found that Blautia spp. and Streptococcus spp. were two most associated species in RA and these taxa were significantly higher in comparison to healthy controls. In contrast, our findings suggested that Roseburia spp. and Lachnoclostridium spp. were significantly lower in the RA in comparison to healthy controls. In conclusion, RA patients shared similar gut microbiota pattern with their spouses which were different from healthy individuals. The findings suggest that disturbance of the balance of gut microbiota may play an important role in the dynamics of pathogenesis of RA. Frontiers Media S.A. 2020-09-02 /pmc/articles/PMC7931358/ /pubmed/33681234 http://dx.doi.org/10.3389/fmed.2020.00538 Text en Copyright © 2020 Liu, Wu, Luo, Wei, Lu, Zhou, Wang, Miao, Lin, Zhao, Liu and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Liu, Zhihui
Wu, Yuxi
Luo, Yubin
Wei, Shixiong
Lu, Chenyang
Zhou, Yi
Wang, Jing
Miao, Ting
Lin, Hui
Zhao, Yi
Liu, Qi
Liu, Yi
Self-Balance of Intestinal Flora in Spouses of Patients With Rheumatoid Arthritis
title Self-Balance of Intestinal Flora in Spouses of Patients With Rheumatoid Arthritis
title_full Self-Balance of Intestinal Flora in Spouses of Patients With Rheumatoid Arthritis
title_fullStr Self-Balance of Intestinal Flora in Spouses of Patients With Rheumatoid Arthritis
title_full_unstemmed Self-Balance of Intestinal Flora in Spouses of Patients With Rheumatoid Arthritis
title_short Self-Balance of Intestinal Flora in Spouses of Patients With Rheumatoid Arthritis
title_sort self-balance of intestinal flora in spouses of patients with rheumatoid arthritis
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931358/
https://www.ncbi.nlm.nih.gov/pubmed/33681234
http://dx.doi.org/10.3389/fmed.2020.00538
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