Intracellular galectins sense cytosolically exposed glycans as danger and mediate cellular responses

Galectins are animal lectins that recognize carbohydrates and play important roles in maintaining cellular homeostasis. Recent studies have indicated that under a variety of challenges, intracellular galectins bind to host glycans displayed on damaged endocytic vesicles and accumulate around these d...

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Autores principales: Hong, Ming-Hsiang, Weng, I-Chun, Li, Fang-Yen, Lin, Wei-Han, Liu, Fu-Tong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931364/
https://www.ncbi.nlm.nih.gov/pubmed/33663512
http://dx.doi.org/10.1186/s12929-021-00713-x
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author Hong, Ming-Hsiang
Weng, I-Chun
Li, Fang-Yen
Lin, Wei-Han
Liu, Fu-Tong
author_facet Hong, Ming-Hsiang
Weng, I-Chun
Li, Fang-Yen
Lin, Wei-Han
Liu, Fu-Tong
author_sort Hong, Ming-Hsiang
collection PubMed
description Galectins are animal lectins that recognize carbohydrates and play important roles in maintaining cellular homeostasis. Recent studies have indicated that under a variety of challenges, intracellular galectins bind to host glycans displayed on damaged endocytic vesicles and accumulate around these damaged organelles. Accumulated galectins then engage cellular proteins and subsequently control cellular responses, such as autophagy. In this review, we have summarized the stimuli that lead to the accumulation of galectins, the molecular mechanisms of galectin accumulation, and galectin-mediated cellular responses, and elaborate on the differential regulatory effects among galectins.
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spelling pubmed-79313642021-03-05 Intracellular galectins sense cytosolically exposed glycans as danger and mediate cellular responses Hong, Ming-Hsiang Weng, I-Chun Li, Fang-Yen Lin, Wei-Han Liu, Fu-Tong J Biomed Sci Review Galectins are animal lectins that recognize carbohydrates and play important roles in maintaining cellular homeostasis. Recent studies have indicated that under a variety of challenges, intracellular galectins bind to host glycans displayed on damaged endocytic vesicles and accumulate around these damaged organelles. Accumulated galectins then engage cellular proteins and subsequently control cellular responses, such as autophagy. In this review, we have summarized the stimuli that lead to the accumulation of galectins, the molecular mechanisms of galectin accumulation, and galectin-mediated cellular responses, and elaborate on the differential regulatory effects among galectins. BioMed Central 2021-03-04 /pmc/articles/PMC7931364/ /pubmed/33663512 http://dx.doi.org/10.1186/s12929-021-00713-x Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Hong, Ming-Hsiang
Weng, I-Chun
Li, Fang-Yen
Lin, Wei-Han
Liu, Fu-Tong
Intracellular galectins sense cytosolically exposed glycans as danger and mediate cellular responses
title Intracellular galectins sense cytosolically exposed glycans as danger and mediate cellular responses
title_full Intracellular galectins sense cytosolically exposed glycans as danger and mediate cellular responses
title_fullStr Intracellular galectins sense cytosolically exposed glycans as danger and mediate cellular responses
title_full_unstemmed Intracellular galectins sense cytosolically exposed glycans as danger and mediate cellular responses
title_short Intracellular galectins sense cytosolically exposed glycans as danger and mediate cellular responses
title_sort intracellular galectins sense cytosolically exposed glycans as danger and mediate cellular responses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931364/
https://www.ncbi.nlm.nih.gov/pubmed/33663512
http://dx.doi.org/10.1186/s12929-021-00713-x
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