Cargando…

Effect of Lauric Acid on the Stability of Aβ(42) Oligomers

[Image: see text] While Alzheimer’s disease is correlated with the presence of Aβ fibrils in patient brains, the more likely agents are their precursors, soluble oligomers that may form pores or otherwise distort cell membranes. Using all-atom molecular dynamics simulation, we study how the presence...

Descripción completa

Detalles Bibliográficos
Autores principales: Khatua, Prabir, Jana, Asis K., Hansmann, Ulrich H. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931375/
https://www.ncbi.nlm.nih.gov/pubmed/33681618
http://dx.doi.org/10.1021/acsomega.0c06211
_version_ 1783660279235608576
author Khatua, Prabir
Jana, Asis K.
Hansmann, Ulrich H. E.
author_facet Khatua, Prabir
Jana, Asis K.
Hansmann, Ulrich H. E.
author_sort Khatua, Prabir
collection PubMed
description [Image: see text] While Alzheimer’s disease is correlated with the presence of Aβ fibrils in patient brains, the more likely agents are their precursors, soluble oligomers that may form pores or otherwise distort cell membranes. Using all-atom molecular dynamics simulation, we study how the presence of fatty acids such as lauric acid changes the stability of pore-forming oligomers built from three-stranded Aβ(42) chains. Such a change would alter the distribution of amyloids in the fatty acid-rich brain environment and therefore could explain the lower polymorphism observed in Aβ fibrils derived from brains of patients with Alzheimer’s disease. We find that lauric acid stabilizes both ring-like and barrel-shaped models, with the effect being stronger for barrel-like models than for ring-like oligomers.
format Online
Article
Text
id pubmed-7931375
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-79313752021-03-05 Effect of Lauric Acid on the Stability of Aβ(42) Oligomers Khatua, Prabir Jana, Asis K. Hansmann, Ulrich H. E. ACS Omega [Image: see text] While Alzheimer’s disease is correlated with the presence of Aβ fibrils in patient brains, the more likely agents are their precursors, soluble oligomers that may form pores or otherwise distort cell membranes. Using all-atom molecular dynamics simulation, we study how the presence of fatty acids such as lauric acid changes the stability of pore-forming oligomers built from three-stranded Aβ(42) chains. Such a change would alter the distribution of amyloids in the fatty acid-rich brain environment and therefore could explain the lower polymorphism observed in Aβ fibrils derived from brains of patients with Alzheimer’s disease. We find that lauric acid stabilizes both ring-like and barrel-shaped models, with the effect being stronger for barrel-like models than for ring-like oligomers. American Chemical Society 2021-02-17 /pmc/articles/PMC7931375/ /pubmed/33681618 http://dx.doi.org/10.1021/acsomega.0c06211 Text en © 2021 The Authors. Published by American Chemical Society This is an open access article published under an ACS AuthorChoice License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Khatua, Prabir
Jana, Asis K.
Hansmann, Ulrich H. E.
Effect of Lauric Acid on the Stability of Aβ(42) Oligomers
title Effect of Lauric Acid on the Stability of Aβ(42) Oligomers
title_full Effect of Lauric Acid on the Stability of Aβ(42) Oligomers
title_fullStr Effect of Lauric Acid on the Stability of Aβ(42) Oligomers
title_full_unstemmed Effect of Lauric Acid on the Stability of Aβ(42) Oligomers
title_short Effect of Lauric Acid on the Stability of Aβ(42) Oligomers
title_sort effect of lauric acid on the stability of aβ(42) oligomers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931375/
https://www.ncbi.nlm.nih.gov/pubmed/33681618
http://dx.doi.org/10.1021/acsomega.0c06211
work_keys_str_mv AT khatuaprabir effectoflauricacidonthestabilityofab42oligomers
AT janaasisk effectoflauricacidonthestabilityofab42oligomers
AT hansmannulrichhe effectoflauricacidonthestabilityofab42oligomers