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Effect of Lauric Acid on the Stability of Aβ(42) Oligomers
[Image: see text] While Alzheimer’s disease is correlated with the presence of Aβ fibrils in patient brains, the more likely agents are their precursors, soluble oligomers that may form pores or otherwise distort cell membranes. Using all-atom molecular dynamics simulation, we study how the presence...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931375/ https://www.ncbi.nlm.nih.gov/pubmed/33681618 http://dx.doi.org/10.1021/acsomega.0c06211 |
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author | Khatua, Prabir Jana, Asis K. Hansmann, Ulrich H. E. |
author_facet | Khatua, Prabir Jana, Asis K. Hansmann, Ulrich H. E. |
author_sort | Khatua, Prabir |
collection | PubMed |
description | [Image: see text] While Alzheimer’s disease is correlated with the presence of Aβ fibrils in patient brains, the more likely agents are their precursors, soluble oligomers that may form pores or otherwise distort cell membranes. Using all-atom molecular dynamics simulation, we study how the presence of fatty acids such as lauric acid changes the stability of pore-forming oligomers built from three-stranded Aβ(42) chains. Such a change would alter the distribution of amyloids in the fatty acid-rich brain environment and therefore could explain the lower polymorphism observed in Aβ fibrils derived from brains of patients with Alzheimer’s disease. We find that lauric acid stabilizes both ring-like and barrel-shaped models, with the effect being stronger for barrel-like models than for ring-like oligomers. |
format | Online Article Text |
id | pubmed-7931375 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-79313752021-03-05 Effect of Lauric Acid on the Stability of Aβ(42) Oligomers Khatua, Prabir Jana, Asis K. Hansmann, Ulrich H. E. ACS Omega [Image: see text] While Alzheimer’s disease is correlated with the presence of Aβ fibrils in patient brains, the more likely agents are their precursors, soluble oligomers that may form pores or otherwise distort cell membranes. Using all-atom molecular dynamics simulation, we study how the presence of fatty acids such as lauric acid changes the stability of pore-forming oligomers built from three-stranded Aβ(42) chains. Such a change would alter the distribution of amyloids in the fatty acid-rich brain environment and therefore could explain the lower polymorphism observed in Aβ fibrils derived from brains of patients with Alzheimer’s disease. We find that lauric acid stabilizes both ring-like and barrel-shaped models, with the effect being stronger for barrel-like models than for ring-like oligomers. American Chemical Society 2021-02-17 /pmc/articles/PMC7931375/ /pubmed/33681618 http://dx.doi.org/10.1021/acsomega.0c06211 Text en © 2021 The Authors. Published by American Chemical Society This is an open access article published under an ACS AuthorChoice License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
spellingShingle | Khatua, Prabir Jana, Asis K. Hansmann, Ulrich H. E. Effect of Lauric Acid on the Stability of Aβ(42) Oligomers |
title | Effect of Lauric Acid on the Stability of Aβ(42) Oligomers |
title_full | Effect of Lauric Acid on the Stability of Aβ(42) Oligomers |
title_fullStr | Effect of Lauric Acid on the Stability of Aβ(42) Oligomers |
title_full_unstemmed | Effect of Lauric Acid on the Stability of Aβ(42) Oligomers |
title_short | Effect of Lauric Acid on the Stability of Aβ(42) Oligomers |
title_sort | effect of lauric acid on the stability of aβ(42) oligomers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931375/ https://www.ncbi.nlm.nih.gov/pubmed/33681618 http://dx.doi.org/10.1021/acsomega.0c06211 |
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