Linderaggrenolides A–N, Oxygen-Conjugated Sesquiterpenoid Dimers from the Roots of Lindera aggregata

[Image: see text] Linderaggrenolides A–N (1–14), 14 new lindenane sesquiterpenoid dimers with oxygen bridges were isolated from the roots of Lindera aggregata. Their structures were elucidated on the basis of comprehensive spectroscopic data analysis, with the absolute configurations established by...

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Detalles Bibliográficos
Autores principales: Liu, Xin, Fu, Jing, Yang, Ji, Huang, Ancheng C., Li, Run-Feng, Bai, Li-Ping, Liu, Liang, Jiang, Zhi-Hong, Zhu, Guo-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931382/
https://www.ncbi.nlm.nih.gov/pubmed/33681628
http://dx.doi.org/10.1021/acsomega.0c06349
Descripción
Sumario:[Image: see text] Linderaggrenolides A–N (1–14), 14 new lindenane sesquiterpenoid dimers with oxygen bridges were isolated from the roots of Lindera aggregata. Their structures were elucidated on the basis of comprehensive spectroscopic data analysis, with the absolute configurations established by empirical approaches, electronic circular dichroism calculations, and X-ray crystallography. Compounds 8 and 9 were found to exhibit significant transforming growth factor-β inhibitory activity, with IC(50) values of 25.91 and 21.52 μM, respectively.

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