Linderaggrenolides A–N, Oxygen-Conjugated Sesquiterpenoid Dimers from the Roots of Lindera aggregata

[Image: see text] Linderaggrenolides A–N (1–14), 14 new lindenane sesquiterpenoid dimers with oxygen bridges were isolated from the roots of Lindera aggregata. Their structures were elucidated on the basis of comprehensive spectroscopic data analysis, with the absolute configurations established by...

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Autores principales: Liu, Xin, Fu, Jing, Yang, Ji, Huang, Ancheng C., Li, Run-Feng, Bai, Li-Ping, Liu, Liang, Jiang, Zhi-Hong, Zhu, Guo-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931382/
https://www.ncbi.nlm.nih.gov/pubmed/33681628
http://dx.doi.org/10.1021/acsomega.0c06349
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author Liu, Xin
Fu, Jing
Yang, Ji
Huang, Ancheng C.
Li, Run-Feng
Bai, Li-Ping
Liu, Liang
Jiang, Zhi-Hong
Zhu, Guo-Yuan
author_facet Liu, Xin
Fu, Jing
Yang, Ji
Huang, Ancheng C.
Li, Run-Feng
Bai, Li-Ping
Liu, Liang
Jiang, Zhi-Hong
Zhu, Guo-Yuan
author_sort Liu, Xin
collection PubMed
description [Image: see text] Linderaggrenolides A–N (1–14), 14 new lindenane sesquiterpenoid dimers with oxygen bridges were isolated from the roots of Lindera aggregata. Their structures were elucidated on the basis of comprehensive spectroscopic data analysis, with the absolute configurations established by empirical approaches, electronic circular dichroism calculations, and X-ray crystallography. Compounds 8 and 9 were found to exhibit significant transforming growth factor-β inhibitory activity, with IC(50) values of 25.91 and 21.52 μM, respectively.
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spelling pubmed-79313822021-03-05 Linderaggrenolides A–N, Oxygen-Conjugated Sesquiterpenoid Dimers from the Roots of Lindera aggregata Liu, Xin Fu, Jing Yang, Ji Huang, Ancheng C. Li, Run-Feng Bai, Li-Ping Liu, Liang Jiang, Zhi-Hong Zhu, Guo-Yuan ACS Omega [Image: see text] Linderaggrenolides A–N (1–14), 14 new lindenane sesquiterpenoid dimers with oxygen bridges were isolated from the roots of Lindera aggregata. Their structures were elucidated on the basis of comprehensive spectroscopic data analysis, with the absolute configurations established by empirical approaches, electronic circular dichroism calculations, and X-ray crystallography. Compounds 8 and 9 were found to exhibit significant transforming growth factor-β inhibitory activity, with IC(50) values of 25.91 and 21.52 μM, respectively. American Chemical Society 2021-02-16 /pmc/articles/PMC7931382/ /pubmed/33681628 http://dx.doi.org/10.1021/acsomega.0c06349 Text en © 2021 The Authors. Published by American Chemical Society This is an open access article published under an ACS AuthorChoice License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Liu, Xin
Fu, Jing
Yang, Ji
Huang, Ancheng C.
Li, Run-Feng
Bai, Li-Ping
Liu, Liang
Jiang, Zhi-Hong
Zhu, Guo-Yuan
Linderaggrenolides A–N, Oxygen-Conjugated Sesquiterpenoid Dimers from the Roots of Lindera aggregata
title Linderaggrenolides A–N, Oxygen-Conjugated Sesquiterpenoid Dimers from the Roots of Lindera aggregata
title_full Linderaggrenolides A–N, Oxygen-Conjugated Sesquiterpenoid Dimers from the Roots of Lindera aggregata
title_fullStr Linderaggrenolides A–N, Oxygen-Conjugated Sesquiterpenoid Dimers from the Roots of Lindera aggregata
title_full_unstemmed Linderaggrenolides A–N, Oxygen-Conjugated Sesquiterpenoid Dimers from the Roots of Lindera aggregata
title_short Linderaggrenolides A–N, Oxygen-Conjugated Sesquiterpenoid Dimers from the Roots of Lindera aggregata
title_sort linderaggrenolides a–n, oxygen-conjugated sesquiterpenoid dimers from the roots of lindera aggregata
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931382/
https://www.ncbi.nlm.nih.gov/pubmed/33681628
http://dx.doi.org/10.1021/acsomega.0c06349
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