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A Study on the Acoustic Response of Pickering Perfluoropentane Droplets in Different Media

[Image: see text] Acoustic droplet vaporization (ADV) is the physical process of liquid-to-gas phase transition mediated by pressure variations in an ultrasound field. In this study, the acoustic response of novel particle-stabilized perfluoropentane droplets was studied in bulk and confined media....

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Autores principales: Loskutova, Ksenia, Nimander, Didrik, Gouwy, Isabelle, Chen, Hongjian, Ghorbani, Morteza, Svagan, Anna J., Grishenkov, Dmitry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931408/
https://www.ncbi.nlm.nih.gov/pubmed/33681606
http://dx.doi.org/10.1021/acsomega.0c06115
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author Loskutova, Ksenia
Nimander, Didrik
Gouwy, Isabelle
Chen, Hongjian
Ghorbani, Morteza
Svagan, Anna J.
Grishenkov, Dmitry
author_facet Loskutova, Ksenia
Nimander, Didrik
Gouwy, Isabelle
Chen, Hongjian
Ghorbani, Morteza
Svagan, Anna J.
Grishenkov, Dmitry
author_sort Loskutova, Ksenia
collection PubMed
description [Image: see text] Acoustic droplet vaporization (ADV) is the physical process of liquid-to-gas phase transition mediated by pressure variations in an ultrasound field. In this study, the acoustic response of novel particle-stabilized perfluoropentane droplets was studied in bulk and confined media. The oil/water interface was stabilized by cellulose nanofibers. First, their acoustic responses under idealized conditions were examined to assess their susceptibility to undergo ADV. Second, the droplets were studied in a more realistic setting and placed in a confined medium. Lastly, an imaging setup was developed and tested on the droplets. The acoustic response could be seen when the amplitude of the peak negative pressure (PNP) was above 200 kPa, suggesting that this is the vaporization pressure threshold for these droplets. Increasing the PNP resulted in a decrease in signal intensity over time, suggesting a more destructive behavior. The imaging setup was able to differentiate between the droplets and the surrounding tissue. Results obtained within this study suggest that these droplets have potential in terms of ultrasound-mediated diagnostics and therapy.
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spelling pubmed-79314082021-03-05 A Study on the Acoustic Response of Pickering Perfluoropentane Droplets in Different Media Loskutova, Ksenia Nimander, Didrik Gouwy, Isabelle Chen, Hongjian Ghorbani, Morteza Svagan, Anna J. Grishenkov, Dmitry ACS Omega [Image: see text] Acoustic droplet vaporization (ADV) is the physical process of liquid-to-gas phase transition mediated by pressure variations in an ultrasound field. In this study, the acoustic response of novel particle-stabilized perfluoropentane droplets was studied in bulk and confined media. The oil/water interface was stabilized by cellulose nanofibers. First, their acoustic responses under idealized conditions were examined to assess their susceptibility to undergo ADV. Second, the droplets were studied in a more realistic setting and placed in a confined medium. Lastly, an imaging setup was developed and tested on the droplets. The acoustic response could be seen when the amplitude of the peak negative pressure (PNP) was above 200 kPa, suggesting that this is the vaporization pressure threshold for these droplets. Increasing the PNP resulted in a decrease in signal intensity over time, suggesting a more destructive behavior. The imaging setup was able to differentiate between the droplets and the surrounding tissue. Results obtained within this study suggest that these droplets have potential in terms of ultrasound-mediated diagnostics and therapy. American Chemical Society 2021-02-17 /pmc/articles/PMC7931408/ /pubmed/33681606 http://dx.doi.org/10.1021/acsomega.0c06115 Text en © 2021 The Authors. Published by American Chemical Society This is an open access article published under an ACS AuthorChoice License (https://creativecommons.org/licenses/by/4.0/) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Loskutova, Ksenia
Nimander, Didrik
Gouwy, Isabelle
Chen, Hongjian
Ghorbani, Morteza
Svagan, Anna J.
Grishenkov, Dmitry
A Study on the Acoustic Response of Pickering Perfluoropentane Droplets in Different Media
title A Study on the Acoustic Response of Pickering Perfluoropentane Droplets in Different Media
title_full A Study on the Acoustic Response of Pickering Perfluoropentane Droplets in Different Media
title_fullStr A Study on the Acoustic Response of Pickering Perfluoropentane Droplets in Different Media
title_full_unstemmed A Study on the Acoustic Response of Pickering Perfluoropentane Droplets in Different Media
title_short A Study on the Acoustic Response of Pickering Perfluoropentane Droplets in Different Media
title_sort study on the acoustic response of pickering perfluoropentane droplets in different media
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931408/
https://www.ncbi.nlm.nih.gov/pubmed/33681606
http://dx.doi.org/10.1021/acsomega.0c06115
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