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Cu(II)-Containing Metal–Organic Framework with 1D Hexagonal Channels for Cyanosilylation Reaction and Anticancer Activity on Osteosarcoma Cells
[Image: see text] A novel metal–organic framework (MOF) has been produced via Cu(NO(3))(2)·6H(2)O reaction with 3-(1H-tetrazol-5-yl)pyridine (HL) in water, and its chemical formula is {[(Cu(L)(2)(H(2)O)(2)](H(2)O)(8))(n)} (1). Due to its high density of coordinately unsaturated sites along with larg...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931417/ https://www.ncbi.nlm.nih.gov/pubmed/33681624 http://dx.doi.org/10.1021/acsomega.0c06270 |
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author | Luo, Jian Ying, Lv-Fang Zhang, Feng Zhou, Ze Zhang, Yan-Guo |
author_facet | Luo, Jian Ying, Lv-Fang Zhang, Feng Zhou, Ze Zhang, Yan-Guo |
author_sort | Luo, Jian |
collection | PubMed |
description | [Image: see text] A novel metal–organic framework (MOF) has been produced via Cu(NO(3))(2)·6H(2)O reaction with 3-(1H-tetrazol-5-yl)pyridine (HL) in water, and its chemical formula is {[(Cu(L)(2)(H(2)O)(2)](H(2)O)(8))(n)} (1). Due to its high density of coordinately unsaturated sites along with large one-dimensional (1D) hexagonal channels, the activated complex 1 (1a) was explored as the solvent-free heterogeneous catalyst for cyanosilylation under mind conditions. The inhibitory function of compound 1a against the survival rate of OS-732 osteosarcoma cells was evaluated via Cell Counting Kit-8 (CCK-8) detection kit. Furthermore, the Annexin V-FITC/PI detection kit and the active oxygen (ROS) detection kit was carried out to determine the cell apoptosis levels and the ROS accumulation in OS-732 osteosarcoma cells after treatment by compound 1a. |
format | Online Article Text |
id | pubmed-7931417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-79314172021-03-05 Cu(II)-Containing Metal–Organic Framework with 1D Hexagonal Channels for Cyanosilylation Reaction and Anticancer Activity on Osteosarcoma Cells Luo, Jian Ying, Lv-Fang Zhang, Feng Zhou, Ze Zhang, Yan-Guo ACS Omega [Image: see text] A novel metal–organic framework (MOF) has been produced via Cu(NO(3))(2)·6H(2)O reaction with 3-(1H-tetrazol-5-yl)pyridine (HL) in water, and its chemical formula is {[(Cu(L)(2)(H(2)O)(2)](H(2)O)(8))(n)} (1). Due to its high density of coordinately unsaturated sites along with large one-dimensional (1D) hexagonal channels, the activated complex 1 (1a) was explored as the solvent-free heterogeneous catalyst for cyanosilylation under mind conditions. The inhibitory function of compound 1a against the survival rate of OS-732 osteosarcoma cells was evaluated via Cell Counting Kit-8 (CCK-8) detection kit. Furthermore, the Annexin V-FITC/PI detection kit and the active oxygen (ROS) detection kit was carried out to determine the cell apoptosis levels and the ROS accumulation in OS-732 osteosarcoma cells after treatment by compound 1a. American Chemical Society 2021-02-18 /pmc/articles/PMC7931417/ /pubmed/33681624 http://dx.doi.org/10.1021/acsomega.0c06270 Text en © 2021 The Authors. Published by American Chemical Society This is an open access article published under an ACS AuthorChoice License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
spellingShingle | Luo, Jian Ying, Lv-Fang Zhang, Feng Zhou, Ze Zhang, Yan-Guo Cu(II)-Containing Metal–Organic Framework with 1D Hexagonal Channels for Cyanosilylation Reaction and Anticancer Activity on Osteosarcoma Cells |
title | Cu(II)-Containing Metal–Organic Framework with
1D Hexagonal Channels for Cyanosilylation Reaction and Anticancer
Activity on Osteosarcoma Cells |
title_full | Cu(II)-Containing Metal–Organic Framework with
1D Hexagonal Channels for Cyanosilylation Reaction and Anticancer
Activity on Osteosarcoma Cells |
title_fullStr | Cu(II)-Containing Metal–Organic Framework with
1D Hexagonal Channels for Cyanosilylation Reaction and Anticancer
Activity on Osteosarcoma Cells |
title_full_unstemmed | Cu(II)-Containing Metal–Organic Framework with
1D Hexagonal Channels for Cyanosilylation Reaction and Anticancer
Activity on Osteosarcoma Cells |
title_short | Cu(II)-Containing Metal–Organic Framework with
1D Hexagonal Channels for Cyanosilylation Reaction and Anticancer
Activity on Osteosarcoma Cells |
title_sort | cu(ii)-containing metal–organic framework with
1d hexagonal channels for cyanosilylation reaction and anticancer
activity on osteosarcoma cells |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931417/ https://www.ncbi.nlm.nih.gov/pubmed/33681624 http://dx.doi.org/10.1021/acsomega.0c06270 |
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