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Cu(II)-Containing Metal–Organic Framework with 1D Hexagonal Channels for Cyanosilylation Reaction and Anticancer Activity on Osteosarcoma Cells

[Image: see text] A novel metal–organic framework (MOF) has been produced via Cu(NO(3))(2)·6H(2)O reaction with 3-(1H-tetrazol-5-yl)pyridine (HL) in water, and its chemical formula is {[(Cu(L)(2)(H(2)O)(2)](H(2)O)(8))(n)} (1). Due to its high density of coordinately unsaturated sites along with larg...

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Autores principales: Luo, Jian, Ying, Lv-Fang, Zhang, Feng, Zhou, Ze, Zhang, Yan-Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931417/
https://www.ncbi.nlm.nih.gov/pubmed/33681624
http://dx.doi.org/10.1021/acsomega.0c06270
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author Luo, Jian
Ying, Lv-Fang
Zhang, Feng
Zhou, Ze
Zhang, Yan-Guo
author_facet Luo, Jian
Ying, Lv-Fang
Zhang, Feng
Zhou, Ze
Zhang, Yan-Guo
author_sort Luo, Jian
collection PubMed
description [Image: see text] A novel metal–organic framework (MOF) has been produced via Cu(NO(3))(2)·6H(2)O reaction with 3-(1H-tetrazol-5-yl)pyridine (HL) in water, and its chemical formula is {[(Cu(L)(2)(H(2)O)(2)](H(2)O)(8))(n)} (1). Due to its high density of coordinately unsaturated sites along with large one-dimensional (1D) hexagonal channels, the activated complex 1 (1a) was explored as the solvent-free heterogeneous catalyst for cyanosilylation under mind conditions. The inhibitory function of compound 1a against the survival rate of OS-732 osteosarcoma cells was evaluated via Cell Counting Kit-8 (CCK-8) detection kit. Furthermore, the Annexin V-FITC/PI detection kit and the active oxygen (ROS) detection kit was carried out to determine the cell apoptosis levels and the ROS accumulation in OS-732 osteosarcoma cells after treatment by compound 1a.
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spelling pubmed-79314172021-03-05 Cu(II)-Containing Metal–Organic Framework with 1D Hexagonal Channels for Cyanosilylation Reaction and Anticancer Activity on Osteosarcoma Cells Luo, Jian Ying, Lv-Fang Zhang, Feng Zhou, Ze Zhang, Yan-Guo ACS Omega [Image: see text] A novel metal–organic framework (MOF) has been produced via Cu(NO(3))(2)·6H(2)O reaction with 3-(1H-tetrazol-5-yl)pyridine (HL) in water, and its chemical formula is {[(Cu(L)(2)(H(2)O)(2)](H(2)O)(8))(n)} (1). Due to its high density of coordinately unsaturated sites along with large one-dimensional (1D) hexagonal channels, the activated complex 1 (1a) was explored as the solvent-free heterogeneous catalyst for cyanosilylation under mind conditions. The inhibitory function of compound 1a against the survival rate of OS-732 osteosarcoma cells was evaluated via Cell Counting Kit-8 (CCK-8) detection kit. Furthermore, the Annexin V-FITC/PI detection kit and the active oxygen (ROS) detection kit was carried out to determine the cell apoptosis levels and the ROS accumulation in OS-732 osteosarcoma cells after treatment by compound 1a. American Chemical Society 2021-02-18 /pmc/articles/PMC7931417/ /pubmed/33681624 http://dx.doi.org/10.1021/acsomega.0c06270 Text en © 2021 The Authors. Published by American Chemical Society This is an open access article published under an ACS AuthorChoice License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Luo, Jian
Ying, Lv-Fang
Zhang, Feng
Zhou, Ze
Zhang, Yan-Guo
Cu(II)-Containing Metal–Organic Framework with 1D Hexagonal Channels for Cyanosilylation Reaction and Anticancer Activity on Osteosarcoma Cells
title Cu(II)-Containing Metal–Organic Framework with 1D Hexagonal Channels for Cyanosilylation Reaction and Anticancer Activity on Osteosarcoma Cells
title_full Cu(II)-Containing Metal–Organic Framework with 1D Hexagonal Channels for Cyanosilylation Reaction and Anticancer Activity on Osteosarcoma Cells
title_fullStr Cu(II)-Containing Metal–Organic Framework with 1D Hexagonal Channels for Cyanosilylation Reaction and Anticancer Activity on Osteosarcoma Cells
title_full_unstemmed Cu(II)-Containing Metal–Organic Framework with 1D Hexagonal Channels for Cyanosilylation Reaction and Anticancer Activity on Osteosarcoma Cells
title_short Cu(II)-Containing Metal–Organic Framework with 1D Hexagonal Channels for Cyanosilylation Reaction and Anticancer Activity on Osteosarcoma Cells
title_sort cu(ii)-containing metal–organic framework with 1d hexagonal channels for cyanosilylation reaction and anticancer activity on osteosarcoma cells
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931417/
https://www.ncbi.nlm.nih.gov/pubmed/33681624
http://dx.doi.org/10.1021/acsomega.0c06270
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