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Gastro-esophageal reflux disease and Barrett’s esophagus: an overview with an histologic diagnostic approach

The first part of this overview on non-neoplastic esophagus is focused on gastro-esophageal reflux disease (GERD) and Barrett’s esophagus. In the last 20 years much has changed in histological approach to biopsies of patients with gastro-esophageal reflux disease. In particular, elementary histologi...

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Autores principales: Mastracci, Luca, Grillo, Federica, Parente, Paola, Unti, Elettra, Battista, Serena, Spaggiari, Paola, Campora, Michela, Scaglione, Giulia, Fassan, Matteo, Fiocca, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pacini Editore srl 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931578/
https://www.ncbi.nlm.nih.gov/pubmed/33179616
http://dx.doi.org/10.32074/1591-951X-162
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author Mastracci, Luca
Grillo, Federica
Parente, Paola
Unti, Elettra
Battista, Serena
Spaggiari, Paola
Campora, Michela
Scaglione, Giulia
Fassan, Matteo
Fiocca, Roberto
author_facet Mastracci, Luca
Grillo, Federica
Parente, Paola
Unti, Elettra
Battista, Serena
Spaggiari, Paola
Campora, Michela
Scaglione, Giulia
Fassan, Matteo
Fiocca, Roberto
author_sort Mastracci, Luca
collection PubMed
description The first part of this overview on non-neoplastic esophagus is focused on gastro-esophageal reflux disease (GERD) and Barrett’s esophagus. In the last 20 years much has changed in histological approach to biopsies of patients with gastro-esophageal reflux disease. In particular, elementary histologic lesions have been well defined and modality of evaluation and grade are detailed, their sensitivity and specificity has been evaluated and their use has been validated by several authors. Also if there is not a clinical indication to perform biopsies in patient with GERD, the diagnosis of microscopic esophagitis, when biopsies are provided, can be performed by following simple rules for evaluation which allow pathologists to make the diagnosis with confidence. On the other hand, biopsies are required for the diagnosis of Barrett’s esophagus. This diagnosis is the synthesis of endoscopic picture (which has to be provided with the proper description on extent and with adequate biopsies number) and histologic pattern. The current guidelines and expert opinions for the correct management of these diagnosis are detailed.
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spelling pubmed-79315782021-07-08 Gastro-esophageal reflux disease and Barrett’s esophagus: an overview with an histologic diagnostic approach Mastracci, Luca Grillo, Federica Parente, Paola Unti, Elettra Battista, Serena Spaggiari, Paola Campora, Michela Scaglione, Giulia Fassan, Matteo Fiocca, Roberto Pathologica Review The first part of this overview on non-neoplastic esophagus is focused on gastro-esophageal reflux disease (GERD) and Barrett’s esophagus. In the last 20 years much has changed in histological approach to biopsies of patients with gastro-esophageal reflux disease. In particular, elementary histologic lesions have been well defined and modality of evaluation and grade are detailed, their sensitivity and specificity has been evaluated and their use has been validated by several authors. Also if there is not a clinical indication to perform biopsies in patient with GERD, the diagnosis of microscopic esophagitis, when biopsies are provided, can be performed by following simple rules for evaluation which allow pathologists to make the diagnosis with confidence. On the other hand, biopsies are required for the diagnosis of Barrett’s esophagus. This diagnosis is the synthesis of endoscopic picture (which has to be provided with the proper description on extent and with adequate biopsies number) and histologic pattern. The current guidelines and expert opinions for the correct management of these diagnosis are detailed. Pacini Editore srl 2020-10-29 /pmc/articles/PMC7931578/ /pubmed/33179616 http://dx.doi.org/10.32074/1591-951X-162 Text en © 2020 Copyright by Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en This is an open access journal distributed in accordance with the CC-BY-NC-ND (Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International) license: the work can be used by mentioning the author and the license, but only for non-commercial purposes and only in the original version. For further information: https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en
spellingShingle Review
Mastracci, Luca
Grillo, Federica
Parente, Paola
Unti, Elettra
Battista, Serena
Spaggiari, Paola
Campora, Michela
Scaglione, Giulia
Fassan, Matteo
Fiocca, Roberto
Gastro-esophageal reflux disease and Barrett’s esophagus: an overview with an histologic diagnostic approach
title Gastro-esophageal reflux disease and Barrett’s esophagus: an overview with an histologic diagnostic approach
title_full Gastro-esophageal reflux disease and Barrett’s esophagus: an overview with an histologic diagnostic approach
title_fullStr Gastro-esophageal reflux disease and Barrett’s esophagus: an overview with an histologic diagnostic approach
title_full_unstemmed Gastro-esophageal reflux disease and Barrett’s esophagus: an overview with an histologic diagnostic approach
title_short Gastro-esophageal reflux disease and Barrett’s esophagus: an overview with an histologic diagnostic approach
title_sort gastro-esophageal reflux disease and barrett’s esophagus: an overview with an histologic diagnostic approach
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931578/
https://www.ncbi.nlm.nih.gov/pubmed/33179616
http://dx.doi.org/10.32074/1591-951X-162
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