Human mesenchymal stem cell treatment of premature ovarian failure: new challenges and opportunities

Premature ovarian failure (POF) is one of the common disorders found in women leading to 1% female infertility. Clinical features of POF are hypoestrogenism or estrogen deficiency, increased gonadotropin level, and, most importantly, amenorrhea. With the development of regenerative medicine, human m...

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Autores principales: Fu, Yun-Xing, Ji, Jing, Shan, Fang, Li, Jialing, Hu, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931610/
https://www.ncbi.nlm.nih.gov/pubmed/33658073
http://dx.doi.org/10.1186/s13287-021-02212-0
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author Fu, Yun-Xing
Ji, Jing
Shan, Fang
Li, Jialing
Hu, Rong
author_facet Fu, Yun-Xing
Ji, Jing
Shan, Fang
Li, Jialing
Hu, Rong
author_sort Fu, Yun-Xing
collection PubMed
description Premature ovarian failure (POF) is one of the common disorders found in women leading to 1% female infertility. Clinical features of POF are hypoestrogenism or estrogen deficiency, increased gonadotropin level, and, most importantly, amenorrhea. With the development of regenerative medicine, human mesenchymal stem cell (hMSC) therapy brings new prospects for POF. This study aimed to describe the types of MSCs currently available for POF therapy, their biological characteristics, and their mechanism of action. It reviewed the latest findings on POF to provide the theoretical basis for further investigation and clinical therapy.
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spelling pubmed-79316102021-03-05 Human mesenchymal stem cell treatment of premature ovarian failure: new challenges and opportunities Fu, Yun-Xing Ji, Jing Shan, Fang Li, Jialing Hu, Rong Stem Cell Res Ther Review Premature ovarian failure (POF) is one of the common disorders found in women leading to 1% female infertility. Clinical features of POF are hypoestrogenism or estrogen deficiency, increased gonadotropin level, and, most importantly, amenorrhea. With the development of regenerative medicine, human mesenchymal stem cell (hMSC) therapy brings new prospects for POF. This study aimed to describe the types of MSCs currently available for POF therapy, their biological characteristics, and their mechanism of action. It reviewed the latest findings on POF to provide the theoretical basis for further investigation and clinical therapy. BioMed Central 2021-03-03 /pmc/articles/PMC7931610/ /pubmed/33658073 http://dx.doi.org/10.1186/s13287-021-02212-0 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Fu, Yun-Xing
Ji, Jing
Shan, Fang
Li, Jialing
Hu, Rong
Human mesenchymal stem cell treatment of premature ovarian failure: new challenges and opportunities
title Human mesenchymal stem cell treatment of premature ovarian failure: new challenges and opportunities
title_full Human mesenchymal stem cell treatment of premature ovarian failure: new challenges and opportunities
title_fullStr Human mesenchymal stem cell treatment of premature ovarian failure: new challenges and opportunities
title_full_unstemmed Human mesenchymal stem cell treatment of premature ovarian failure: new challenges and opportunities
title_short Human mesenchymal stem cell treatment of premature ovarian failure: new challenges and opportunities
title_sort human mesenchymal stem cell treatment of premature ovarian failure: new challenges and opportunities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931610/
https://www.ncbi.nlm.nih.gov/pubmed/33658073
http://dx.doi.org/10.1186/s13287-021-02212-0
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