Cargando…
Phase separation of Axin organizes the β-catenin destruction complex
In Wnt/β-catenin signaling, the β-catenin protein level is deliberately controlled by the assembly of the multiprotein β-catenin destruction complex composed of Axin, adenomatous polyposis coli (APC), glycogen synthase kinase 3β (GSK3β), casein kinase 1α (CK1α), and others. Here we provide compellin...
Autores principales: | Nong, Junxiu, Kang, Kexin, Shi, Qiaoni, Zhu, Xuechen, Tao, Qinghua, Chen, Ye-Guang |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931644/ https://www.ncbi.nlm.nih.gov/pubmed/33651074 http://dx.doi.org/10.1083/jcb.202012112 |
Ejemplares similares
-
Dishevelled phase separation promotes Wnt signalosome assembly and destruction complex disassembly
por: Kang, Kexin, et al.
Publicado: (2022) -
Letting go: Dishevelled phase separation recruits Axin to stabilize β-catenin
por: Babcock, Rachel L., et al.
Publicado: (2022) -
UCHL5 controls β-catenin destruction complex function through Axin1 regulation
por: Han, Wonhee, et al.
Publicado: (2022) -
Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation
por: Ranes, Michael, et al.
Publicado: (2021) -
Expression of β-catenin and AXIN2 in ameloblastomas
por: Wei, Zhenhui, et al.
Publicado: (2013)