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Interleukin 6 and depression in patients affected by Covid-19()

INTRODUCTION: Rise of central cytokines resulting from infections produces neuronal changes. Covid-19 allows the study of depressive symptoms in sustained stress and its relationship with molecular mechanisms. OBJECTIVES: To assess correlation between IL-6, IL-1β and TNF-α and depressive symptoms. C...

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Detalles Bibliográficos
Autores principales: Serrano García, Antonio, Montánchez Mateo, Judith, Franch Pato, Clara Margarita, Gómez Martínez, Rocío, García Vázquez, Paula, González Rodríguez, Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier España, S.L.U. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931695/
https://www.ncbi.nlm.nih.gov/pubmed/33688583
http://dx.doi.org/10.1016/j.medcle.2020.11.013
Descripción
Sumario:INTRODUCTION: Rise of central cytokines resulting from infections produces neuronal changes. Covid-19 allows the study of depressive symptoms in sustained stress and its relationship with molecular mechanisms. OBJECTIVES: To assess correlation between IL-6, IL-1β and TNF-α and depressive symptoms. Characterize the depressive symptoms present. METHODS: Observational study. Patients admitted for Covid-19 older than 60 years with a interleukin determination were included. The Yesavage Geriatric Depression Scale was used, associating each item with a neurotransmitter. RESULTS: 27 patients included. We did not find correlation between IL-6 levels and the GDS scale score (rho = 0.204; 95% CI −0.192 to 0.543); with IL-1β levels (rho = −0.126; 95% CI −0.490 to 0.276); nor of TNF-α (rho = −0.033; 95% CI −0.416 to 0.360). 3 patients (11.1%) presented score compatible with depressive disorder. It was associated with a deficiency of Noradrenaline and Serotonin. CONCLUSIONS: We found no correlation between the levels of IL-6, IL-1β, and TNF-α with the GDS score. Depressive symptomatology is similar to vascular depressions.