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Inferring True COVID19 Infection Rates From Deaths
The novel coronavirus, SARS-CoV-2, commonly known as COVID19 has become a global pandemic in early 2020. The world has mounted a global social distancing intervention on a scale thought unimaginable prior to this outbreak; however, the economic impact and sustainability limits of this policy create...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931884/ https://www.ncbi.nlm.nih.gov/pubmed/33693416 http://dx.doi.org/10.3389/fdata.2020.565589 |
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author | McCulloh, Ian Kiernan, Kevin Kent, Trevor |
author_facet | McCulloh, Ian Kiernan, Kevin Kent, Trevor |
author_sort | McCulloh, Ian |
collection | PubMed |
description | The novel coronavirus, SARS-CoV-2, commonly known as COVID19 has become a global pandemic in early 2020. The world has mounted a global social distancing intervention on a scale thought unimaginable prior to this outbreak; however, the economic impact and sustainability limits of this policy create significant challenges for government leaders around the world. Understanding the future spread and growth of COVID19 is further complicated by data quality issues due to high numbers of asymptomatic patients who may transmit the disease yet show no symptoms; lack of testing resources; failure of recovered patients to be counted; delays in reporting hospitalizations and deaths; and the co-morbidity of other life-threatening illnesses. We propose a Monte Carlo method for inferring true case counts from observed deaths using clinical estimates of Infection Fatality Ratios and Time to Death. Findings indicate that current COVID19 confirmed positive counts represent a small fraction of actual cases, and that even relatively effective surveillance regimes fail to identify all infectious individuals. We further demonstrate that the miscount also distorts officials' ability to discern the peak of an epidemic, confounding efforts to assess the efficacy of various interventions. |
format | Online Article Text |
id | pubmed-7931884 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79318842021-03-09 Inferring True COVID19 Infection Rates From Deaths McCulloh, Ian Kiernan, Kevin Kent, Trevor Front Big Data Big Data The novel coronavirus, SARS-CoV-2, commonly known as COVID19 has become a global pandemic in early 2020. The world has mounted a global social distancing intervention on a scale thought unimaginable prior to this outbreak; however, the economic impact and sustainability limits of this policy create significant challenges for government leaders around the world. Understanding the future spread and growth of COVID19 is further complicated by data quality issues due to high numbers of asymptomatic patients who may transmit the disease yet show no symptoms; lack of testing resources; failure of recovered patients to be counted; delays in reporting hospitalizations and deaths; and the co-morbidity of other life-threatening illnesses. We propose a Monte Carlo method for inferring true case counts from observed deaths using clinical estimates of Infection Fatality Ratios and Time to Death. Findings indicate that current COVID19 confirmed positive counts represent a small fraction of actual cases, and that even relatively effective surveillance regimes fail to identify all infectious individuals. We further demonstrate that the miscount also distorts officials' ability to discern the peak of an epidemic, confounding efforts to assess the efficacy of various interventions. Frontiers Media S.A. 2020-10-15 /pmc/articles/PMC7931884/ /pubmed/33693416 http://dx.doi.org/10.3389/fdata.2020.565589 Text en Copyright © 2020 McCulloh, Kiernan and Kent. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Big Data McCulloh, Ian Kiernan, Kevin Kent, Trevor Inferring True COVID19 Infection Rates From Deaths |
title | Inferring True COVID19 Infection Rates From Deaths |
title_full | Inferring True COVID19 Infection Rates From Deaths |
title_fullStr | Inferring True COVID19 Infection Rates From Deaths |
title_full_unstemmed | Inferring True COVID19 Infection Rates From Deaths |
title_short | Inferring True COVID19 Infection Rates From Deaths |
title_sort | inferring true covid19 infection rates from deaths |
topic | Big Data |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931884/ https://www.ncbi.nlm.nih.gov/pubmed/33693416 http://dx.doi.org/10.3389/fdata.2020.565589 |
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