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Inferring True COVID19 Infection Rates From Deaths

The novel coronavirus, SARS-CoV-2, commonly known as COVID19 has become a global pandemic in early 2020. The world has mounted a global social distancing intervention on a scale thought unimaginable prior to this outbreak; however, the economic impact and sustainability limits of this policy create...

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Detalles Bibliográficos
Autores principales: McCulloh, Ian, Kiernan, Kevin, Kent, Trevor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931884/
https://www.ncbi.nlm.nih.gov/pubmed/33693416
http://dx.doi.org/10.3389/fdata.2020.565589
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author McCulloh, Ian
Kiernan, Kevin
Kent, Trevor
author_facet McCulloh, Ian
Kiernan, Kevin
Kent, Trevor
author_sort McCulloh, Ian
collection PubMed
description The novel coronavirus, SARS-CoV-2, commonly known as COVID19 has become a global pandemic in early 2020. The world has mounted a global social distancing intervention on a scale thought unimaginable prior to this outbreak; however, the economic impact and sustainability limits of this policy create significant challenges for government leaders around the world. Understanding the future spread and growth of COVID19 is further complicated by data quality issues due to high numbers of asymptomatic patients who may transmit the disease yet show no symptoms; lack of testing resources; failure of recovered patients to be counted; delays in reporting hospitalizations and deaths; and the co-morbidity of other life-threatening illnesses. We propose a Monte Carlo method for inferring true case counts from observed deaths using clinical estimates of Infection Fatality Ratios and Time to Death. Findings indicate that current COVID19 confirmed positive counts represent a small fraction of actual cases, and that even relatively effective surveillance regimes fail to identify all infectious individuals. We further demonstrate that the miscount also distorts officials' ability to discern the peak of an epidemic, confounding efforts to assess the efficacy of various interventions.
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spelling pubmed-79318842021-03-09 Inferring True COVID19 Infection Rates From Deaths McCulloh, Ian Kiernan, Kevin Kent, Trevor Front Big Data Big Data The novel coronavirus, SARS-CoV-2, commonly known as COVID19 has become a global pandemic in early 2020. The world has mounted a global social distancing intervention on a scale thought unimaginable prior to this outbreak; however, the economic impact and sustainability limits of this policy create significant challenges for government leaders around the world. Understanding the future spread and growth of COVID19 is further complicated by data quality issues due to high numbers of asymptomatic patients who may transmit the disease yet show no symptoms; lack of testing resources; failure of recovered patients to be counted; delays in reporting hospitalizations and deaths; and the co-morbidity of other life-threatening illnesses. We propose a Monte Carlo method for inferring true case counts from observed deaths using clinical estimates of Infection Fatality Ratios and Time to Death. Findings indicate that current COVID19 confirmed positive counts represent a small fraction of actual cases, and that even relatively effective surveillance regimes fail to identify all infectious individuals. We further demonstrate that the miscount also distorts officials' ability to discern the peak of an epidemic, confounding efforts to assess the efficacy of various interventions. Frontiers Media S.A. 2020-10-15 /pmc/articles/PMC7931884/ /pubmed/33693416 http://dx.doi.org/10.3389/fdata.2020.565589 Text en Copyright © 2020 McCulloh, Kiernan and Kent. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Big Data
McCulloh, Ian
Kiernan, Kevin
Kent, Trevor
Inferring True COVID19 Infection Rates From Deaths
title Inferring True COVID19 Infection Rates From Deaths
title_full Inferring True COVID19 Infection Rates From Deaths
title_fullStr Inferring True COVID19 Infection Rates From Deaths
title_full_unstemmed Inferring True COVID19 Infection Rates From Deaths
title_short Inferring True COVID19 Infection Rates From Deaths
title_sort inferring true covid19 infection rates from deaths
topic Big Data
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931884/
https://www.ncbi.nlm.nih.gov/pubmed/33693416
http://dx.doi.org/10.3389/fdata.2020.565589
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