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The prognostic value of serum albumin levels and respiratory rate for community-acquired pneumonia: A prospective, multi-center study
Community-acquired pneumonia (CAP) is a respiratory disease frequently requiring hospital admission, and a significant cause of death worldwide. This study aimed to investigate the prognostic value of clinical indicators. A prospective, multi-center study was conducted (January 2017–December 2018) w...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7932099/ https://www.ncbi.nlm.nih.gov/pubmed/33662036 http://dx.doi.org/10.1371/journal.pone.0248002 |
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author | Zhao, Lili Bao, Jing Shang, Ying Zhang, Ying Yin, Lu Yu, Yan Xie, Yu Chen, Li Zheng, Yali Xu, Yu Gao, Zhancheng |
author_facet | Zhao, Lili Bao, Jing Shang, Ying Zhang, Ying Yin, Lu Yu, Yan Xie, Yu Chen, Li Zheng, Yali Xu, Yu Gao, Zhancheng |
author_sort | Zhao, Lili |
collection | PubMed |
description | Community-acquired pneumonia (CAP) is a respiratory disease frequently requiring hospital admission, and a significant cause of death worldwide. This study aimed to investigate the prognostic value of clinical indicators. A prospective, multi-center study was conducted (January 2017–December 2018) where patient demographic and clinical data were recorded (N = 366). The 30-day mortality rate was 5.46%. Cox Regression analyses showed that serum albumin (ALB) and respiratory rate (RR) were independent prognostic variables for 30-day survival in patients with CAP. Albumin negatively correlated with the Pneumonia Severity Index (PSI) and CURB-65 scores using Pearson and Spearman tests. Survival curves showed that a RR >24 breaths/min or ALB ≤30 g/L were associated with a significantly higher risk of mortality. The area-under-the-curve (AUC) for predicting 30-day mortality in patients with CAP was 0.762, 0.763, 0.790, and 0.784 for ALB, RR, PSI, and CURB-65, respectively. The AUC for the prediction of 30-day mortality using ALB combined with PSI, CURB-65 scores, and RR was 0.822 (95% CI 0.731–0.912), 0.847 (95% CI 0.755–0.938), and 0.847 (95% CI 0.738–0.955), respectively. Albumin and RR were found to be reliable prognostic factors for CAP. This combination showed equal predictive value when compared to adding ALB assessment to PSI and CURB-65 scores, which could improve their prognostic accuracy. |
format | Online Article Text |
id | pubmed-7932099 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-79320992021-03-10 The prognostic value of serum albumin levels and respiratory rate for community-acquired pneumonia: A prospective, multi-center study Zhao, Lili Bao, Jing Shang, Ying Zhang, Ying Yin, Lu Yu, Yan Xie, Yu Chen, Li Zheng, Yali Xu, Yu Gao, Zhancheng PLoS One Research Article Community-acquired pneumonia (CAP) is a respiratory disease frequently requiring hospital admission, and a significant cause of death worldwide. This study aimed to investigate the prognostic value of clinical indicators. A prospective, multi-center study was conducted (January 2017–December 2018) where patient demographic and clinical data were recorded (N = 366). The 30-day mortality rate was 5.46%. Cox Regression analyses showed that serum albumin (ALB) and respiratory rate (RR) were independent prognostic variables for 30-day survival in patients with CAP. Albumin negatively correlated with the Pneumonia Severity Index (PSI) and CURB-65 scores using Pearson and Spearman tests. Survival curves showed that a RR >24 breaths/min or ALB ≤30 g/L were associated with a significantly higher risk of mortality. The area-under-the-curve (AUC) for predicting 30-day mortality in patients with CAP was 0.762, 0.763, 0.790, and 0.784 for ALB, RR, PSI, and CURB-65, respectively. The AUC for the prediction of 30-day mortality using ALB combined with PSI, CURB-65 scores, and RR was 0.822 (95% CI 0.731–0.912), 0.847 (95% CI 0.755–0.938), and 0.847 (95% CI 0.738–0.955), respectively. Albumin and RR were found to be reliable prognostic factors for CAP. This combination showed equal predictive value when compared to adding ALB assessment to PSI and CURB-65 scores, which could improve their prognostic accuracy. Public Library of Science 2021-03-04 /pmc/articles/PMC7932099/ /pubmed/33662036 http://dx.doi.org/10.1371/journal.pone.0248002 Text en © 2021 Zhao et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Zhao, Lili Bao, Jing Shang, Ying Zhang, Ying Yin, Lu Yu, Yan Xie, Yu Chen, Li Zheng, Yali Xu, Yu Gao, Zhancheng The prognostic value of serum albumin levels and respiratory rate for community-acquired pneumonia: A prospective, multi-center study |
title | The prognostic value of serum albumin levels and respiratory rate for community-acquired pneumonia: A prospective, multi-center study |
title_full | The prognostic value of serum albumin levels and respiratory rate for community-acquired pneumonia: A prospective, multi-center study |
title_fullStr | The prognostic value of serum albumin levels and respiratory rate for community-acquired pneumonia: A prospective, multi-center study |
title_full_unstemmed | The prognostic value of serum albumin levels and respiratory rate for community-acquired pneumonia: A prospective, multi-center study |
title_short | The prognostic value of serum albumin levels and respiratory rate for community-acquired pneumonia: A prospective, multi-center study |
title_sort | prognostic value of serum albumin levels and respiratory rate for community-acquired pneumonia: a prospective, multi-center study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7932099/ https://www.ncbi.nlm.nih.gov/pubmed/33662036 http://dx.doi.org/10.1371/journal.pone.0248002 |
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