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The prognostic value of serum albumin levels and respiratory rate for community-acquired pneumonia: A prospective, multi-center study

Community-acquired pneumonia (CAP) is a respiratory disease frequently requiring hospital admission, and a significant cause of death worldwide. This study aimed to investigate the prognostic value of clinical indicators. A prospective, multi-center study was conducted (January 2017–December 2018) w...

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Autores principales: Zhao, Lili, Bao, Jing, Shang, Ying, Zhang, Ying, Yin, Lu, Yu, Yan, Xie, Yu, Chen, Li, Zheng, Yali, Xu, Yu, Gao, Zhancheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7932099/
https://www.ncbi.nlm.nih.gov/pubmed/33662036
http://dx.doi.org/10.1371/journal.pone.0248002
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author Zhao, Lili
Bao, Jing
Shang, Ying
Zhang, Ying
Yin, Lu
Yu, Yan
Xie, Yu
Chen, Li
Zheng, Yali
Xu, Yu
Gao, Zhancheng
author_facet Zhao, Lili
Bao, Jing
Shang, Ying
Zhang, Ying
Yin, Lu
Yu, Yan
Xie, Yu
Chen, Li
Zheng, Yali
Xu, Yu
Gao, Zhancheng
author_sort Zhao, Lili
collection PubMed
description Community-acquired pneumonia (CAP) is a respiratory disease frequently requiring hospital admission, and a significant cause of death worldwide. This study aimed to investigate the prognostic value of clinical indicators. A prospective, multi-center study was conducted (January 2017–December 2018) where patient demographic and clinical data were recorded (N = 366). The 30-day mortality rate was 5.46%. Cox Regression analyses showed that serum albumin (ALB) and respiratory rate (RR) were independent prognostic variables for 30-day survival in patients with CAP. Albumin negatively correlated with the Pneumonia Severity Index (PSI) and CURB-65 scores using Pearson and Spearman tests. Survival curves showed that a RR >24 breaths/min or ALB ≤30 g/L were associated with a significantly higher risk of mortality. The area-under-the-curve (AUC) for predicting 30-day mortality in patients with CAP was 0.762, 0.763, 0.790, and 0.784 for ALB, RR, PSI, and CURB-65, respectively. The AUC for the prediction of 30-day mortality using ALB combined with PSI, CURB-65 scores, and RR was 0.822 (95% CI 0.731–0.912), 0.847 (95% CI 0.755–0.938), and 0.847 (95% CI 0.738–0.955), respectively. Albumin and RR were found to be reliable prognostic factors for CAP. This combination showed equal predictive value when compared to adding ALB assessment to PSI and CURB-65 scores, which could improve their prognostic accuracy.
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spelling pubmed-79320992021-03-10 The prognostic value of serum albumin levels and respiratory rate for community-acquired pneumonia: A prospective, multi-center study Zhao, Lili Bao, Jing Shang, Ying Zhang, Ying Yin, Lu Yu, Yan Xie, Yu Chen, Li Zheng, Yali Xu, Yu Gao, Zhancheng PLoS One Research Article Community-acquired pneumonia (CAP) is a respiratory disease frequently requiring hospital admission, and a significant cause of death worldwide. This study aimed to investigate the prognostic value of clinical indicators. A prospective, multi-center study was conducted (January 2017–December 2018) where patient demographic and clinical data were recorded (N = 366). The 30-day mortality rate was 5.46%. Cox Regression analyses showed that serum albumin (ALB) and respiratory rate (RR) were independent prognostic variables for 30-day survival in patients with CAP. Albumin negatively correlated with the Pneumonia Severity Index (PSI) and CURB-65 scores using Pearson and Spearman tests. Survival curves showed that a RR >24 breaths/min or ALB ≤30 g/L were associated with a significantly higher risk of mortality. The area-under-the-curve (AUC) for predicting 30-day mortality in patients with CAP was 0.762, 0.763, 0.790, and 0.784 for ALB, RR, PSI, and CURB-65, respectively. The AUC for the prediction of 30-day mortality using ALB combined with PSI, CURB-65 scores, and RR was 0.822 (95% CI 0.731–0.912), 0.847 (95% CI 0.755–0.938), and 0.847 (95% CI 0.738–0.955), respectively. Albumin and RR were found to be reliable prognostic factors for CAP. This combination showed equal predictive value when compared to adding ALB assessment to PSI and CURB-65 scores, which could improve their prognostic accuracy. Public Library of Science 2021-03-04 /pmc/articles/PMC7932099/ /pubmed/33662036 http://dx.doi.org/10.1371/journal.pone.0248002 Text en © 2021 Zhao et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Zhao, Lili
Bao, Jing
Shang, Ying
Zhang, Ying
Yin, Lu
Yu, Yan
Xie, Yu
Chen, Li
Zheng, Yali
Xu, Yu
Gao, Zhancheng
The prognostic value of serum albumin levels and respiratory rate for community-acquired pneumonia: A prospective, multi-center study
title The prognostic value of serum albumin levels and respiratory rate for community-acquired pneumonia: A prospective, multi-center study
title_full The prognostic value of serum albumin levels and respiratory rate for community-acquired pneumonia: A prospective, multi-center study
title_fullStr The prognostic value of serum albumin levels and respiratory rate for community-acquired pneumonia: A prospective, multi-center study
title_full_unstemmed The prognostic value of serum albumin levels and respiratory rate for community-acquired pneumonia: A prospective, multi-center study
title_short The prognostic value of serum albumin levels and respiratory rate for community-acquired pneumonia: A prospective, multi-center study
title_sort prognostic value of serum albumin levels and respiratory rate for community-acquired pneumonia: a prospective, multi-center study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7932099/
https://www.ncbi.nlm.nih.gov/pubmed/33662036
http://dx.doi.org/10.1371/journal.pone.0248002
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