Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread, with devastating consequences. For passive immunization efforts, nanobodies have size and cost advantages over conventional antibodies. In this study, we generated four neutralizing nanobodies th...

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Detalles Bibliográficos
Autores principales: Koenig, Paul-Albert, Das, Hrishikesh, Liu, Hejun, Kümmerer, Beate M., Gohr, Florian N., Jenster, Lea-Marie, Schiffelers, Lisa D. J., Tesfamariam, Yonas M., Uchima, Miki, Wuerth, Jennifer D., Gatterdam, Karl, Ruetalo, Natalia, Christensen, Maria H., Fandrey, Caroline I., Normann, Sabine, Tödtmann, Jan M. P., Pritzl, Steffen, Hanke, Leo, Boos, Jannik, Yuan, Meng, Zhu, Xueyong, Schmid-Burgk, Jonathan L., Kato, Hiroki, Schindler, Michael, Wilson, Ian A., Geyer, Matthias, Ludwig, Kerstin U., Hällberg, B. Martin, Wu, Nicholas C., Schmidt, Florian I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7932109/
https://www.ncbi.nlm.nih.gov/pubmed/33436526
http://dx.doi.org/10.1126/science.abe6230

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