Sildenafil-evoked photoreceptor oxidative stress in vivo is unrelated to impaired visual performance in mice

PURPOSE: The phosphodiesterase inhibitor sildenafil is a promising treatment for neurodegenerative disease, but it can cause oxidative stress in photoreceptors ex vivo and degrade visual performance in humans. Here, we test the hypotheses that in wildtype mice sildenafil causes i) wide-spread photor...

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Detalles Bibliográficos
Autores principales: Berkowitz, Bruce A., Podolsky, Robert H., Lins Childers, Karen, Saadane, Aicha, Kern, Timothy S., Roberts, Robin, Olds, Hailey, Joy, Joydip, Richards, Collin, Rosales, Tilman, Schneider, Michael, Schilling, Brennan, Orchanian, Arthur, Graffice, Emma, Sinan, Kenan, Qian, Haohua, Harp, Lamis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7932139/
https://www.ncbi.nlm.nih.gov/pubmed/33661941
http://dx.doi.org/10.1371/journal.pone.0245161

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