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HP1 proteins compact DNA into mechanically and positionally stable phase separated domains

In mammals, HP1-mediated heterochromatin forms positionally and mechanically stable genomic domains even though the component HP1 paralogs, HP1α, HP1β, and HP1γ, display rapid on-off dynamics. Here, we investigate whether phase-separation by HP1 proteins can explain these biological observations. Us...

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Detalles Bibliográficos
Autores principales:	Keenen, Madeline M, Brown, David, Brennan, Lucy D, Renger, Roman, Khoo, Harrison, Carlson, Christopher R, Huang, Bo, Grill, Stephan W, Narlikar, Geeta J, Redding, Sy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7932698/ https://www.ncbi.nlm.nih.gov/pubmed/33661100 http://dx.doi.org/10.7554/eLife.64563

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