Cargando…
Comparison of IL-17 and FOXP3+ Levels in Maternal and Children Leprosy Patients in Endemic and Nonendemic Areas
Leprosy, a chronic infection caused by M. leprae, has a complex transmission problem that makes eradication programs difficult. New cases and ongoing transmission of leprosy in endemic areas make individuals living in endemic environments vulnerable to leprosy. This can be caused by the dysregulatio...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7932766/ https://www.ncbi.nlm.nih.gov/pubmed/33708252 http://dx.doi.org/10.1155/2021/8879809 |
_version_ | 1783660481141014528 |
---|---|
author | Prakoeswa, Flora Ramona Sigit Maharani, Faradiba Fitriah, Munawaroh Nugraha, Jusak Soebono, Hardyanto Prasetyo, Budi Martini, Santi Husada, Dominicus Notobroto, Hari Basuki Listiawan, Muhammad Yulianto Endaryanto, Anang Prakoeswa, Cita Rosita Sigit |
author_facet | Prakoeswa, Flora Ramona Sigit Maharani, Faradiba Fitriah, Munawaroh Nugraha, Jusak Soebono, Hardyanto Prasetyo, Budi Martini, Santi Husada, Dominicus Notobroto, Hari Basuki Listiawan, Muhammad Yulianto Endaryanto, Anang Prakoeswa, Cita Rosita Sigit |
author_sort | Prakoeswa, Flora Ramona Sigit |
collection | PubMed |
description | Leprosy, a chronic infection caused by M. leprae, has a complex transmission problem that makes eradication programs difficult. New cases and ongoing transmission of leprosy in endemic areas make individuals living in endemic environments vulnerable to leprosy. This can be caused by the dysregulation of immune system in individuals living in leprosy-endemic areas. Although the number of male leprosy patients is higher, female leprosy patients have more impact on the family health status due to close contact with family members, roles in the household, and parenting. This could cause the increased number of children leprosy patients. We investigated the dysregulation of immune system by comparing IL-17 and FOXP3+ levels occurring in maternal and child leprosy patients in endemic and nonendemic areas. The results of the study found a statistically significant difference in IL-17 levels between the MB leprosy patient group and the control group (p=0.048), where higher levels of IL-17 are observed in the control group. A significant difference also was found in FOXP3+ levels between the group of healthy children living in endemic and those living in nonendemic areas (p=0.047), where higher FOXP3+ is observed in the healthy children living in endemic areas group. |
format | Online Article Text |
id | pubmed-7932766 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-79327662021-03-10 Comparison of IL-17 and FOXP3+ Levels in Maternal and Children Leprosy Patients in Endemic and Nonendemic Areas Prakoeswa, Flora Ramona Sigit Maharani, Faradiba Fitriah, Munawaroh Nugraha, Jusak Soebono, Hardyanto Prasetyo, Budi Martini, Santi Husada, Dominicus Notobroto, Hari Basuki Listiawan, Muhammad Yulianto Endaryanto, Anang Prakoeswa, Cita Rosita Sigit Interdiscip Perspect Infect Dis Research Article Leprosy, a chronic infection caused by M. leprae, has a complex transmission problem that makes eradication programs difficult. New cases and ongoing transmission of leprosy in endemic areas make individuals living in endemic environments vulnerable to leprosy. This can be caused by the dysregulation of immune system in individuals living in leprosy-endemic areas. Although the number of male leprosy patients is higher, female leprosy patients have more impact on the family health status due to close contact with family members, roles in the household, and parenting. This could cause the increased number of children leprosy patients. We investigated the dysregulation of immune system by comparing IL-17 and FOXP3+ levels occurring in maternal and child leprosy patients in endemic and nonendemic areas. The results of the study found a statistically significant difference in IL-17 levels between the MB leprosy patient group and the control group (p=0.048), where higher levels of IL-17 are observed in the control group. A significant difference also was found in FOXP3+ levels between the group of healthy children living in endemic and those living in nonendemic areas (p=0.047), where higher FOXP3+ is observed in the healthy children living in endemic areas group. Hindawi 2021-02-24 /pmc/articles/PMC7932766/ /pubmed/33708252 http://dx.doi.org/10.1155/2021/8879809 Text en Copyright © 2021 Flora Ramona Sigit Prakoeswa et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Prakoeswa, Flora Ramona Sigit Maharani, Faradiba Fitriah, Munawaroh Nugraha, Jusak Soebono, Hardyanto Prasetyo, Budi Martini, Santi Husada, Dominicus Notobroto, Hari Basuki Listiawan, Muhammad Yulianto Endaryanto, Anang Prakoeswa, Cita Rosita Sigit Comparison of IL-17 and FOXP3+ Levels in Maternal and Children Leprosy Patients in Endemic and Nonendemic Areas |
title | Comparison of IL-17 and FOXP3+ Levels in Maternal and Children Leprosy Patients in Endemic and Nonendemic Areas |
title_full | Comparison of IL-17 and FOXP3+ Levels in Maternal and Children Leprosy Patients in Endemic and Nonendemic Areas |
title_fullStr | Comparison of IL-17 and FOXP3+ Levels in Maternal and Children Leprosy Patients in Endemic and Nonendemic Areas |
title_full_unstemmed | Comparison of IL-17 and FOXP3+ Levels in Maternal and Children Leprosy Patients in Endemic and Nonendemic Areas |
title_short | Comparison of IL-17 and FOXP3+ Levels in Maternal and Children Leprosy Patients in Endemic and Nonendemic Areas |
title_sort | comparison of il-17 and foxp3+ levels in maternal and children leprosy patients in endemic and nonendemic areas |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7932766/ https://www.ncbi.nlm.nih.gov/pubmed/33708252 http://dx.doi.org/10.1155/2021/8879809 |
work_keys_str_mv | AT prakoeswafloraramonasigit comparisonofil17andfoxp3levelsinmaternalandchildrenleprosypatientsinendemicandnonendemicareas AT maharanifaradiba comparisonofil17andfoxp3levelsinmaternalandchildrenleprosypatientsinendemicandnonendemicareas AT fitriahmunawaroh comparisonofil17andfoxp3levelsinmaternalandchildrenleprosypatientsinendemicandnonendemicareas AT nugrahajusak comparisonofil17andfoxp3levelsinmaternalandchildrenleprosypatientsinendemicandnonendemicareas AT soebonohardyanto comparisonofil17andfoxp3levelsinmaternalandchildrenleprosypatientsinendemicandnonendemicareas AT prasetyobudi comparisonofil17andfoxp3levelsinmaternalandchildrenleprosypatientsinendemicandnonendemicareas AT martinisanti comparisonofil17andfoxp3levelsinmaternalandchildrenleprosypatientsinendemicandnonendemicareas AT husadadominicus comparisonofil17andfoxp3levelsinmaternalandchildrenleprosypatientsinendemicandnonendemicareas AT notobrotoharibasuki comparisonofil17andfoxp3levelsinmaternalandchildrenleprosypatientsinendemicandnonendemicareas AT listiawanmuhammadyulianto comparisonofil17andfoxp3levelsinmaternalandchildrenleprosypatientsinendemicandnonendemicareas AT endaryantoanang comparisonofil17andfoxp3levelsinmaternalandchildrenleprosypatientsinendemicandnonendemicareas AT prakoeswacitarositasigit comparisonofil17andfoxp3levelsinmaternalandchildrenleprosypatientsinendemicandnonendemicareas |