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Serum Vitamin Profile in Oral Lichen Planus Patients in Southwest of Iran

INTRODUCTION: Oral lichen planus (OLP) is a chronic mucocutaneous disease. It is mainly an immune system-related disorder. Vitamins can modulate immune system functions, and thus, vitamin deficiency might have roles in exacerbating OLP. We aim to determine the serum levels of vitamins A, B12, C, D3,...

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Autores principales: Rezazadeh, Fahimeh, Haghighat, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7932776/
https://www.ncbi.nlm.nih.gov/pubmed/33708994
http://dx.doi.org/10.1155/2021/8627435
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author Rezazadeh, Fahimeh
Haghighat, Sara
author_facet Rezazadeh, Fahimeh
Haghighat, Sara
author_sort Rezazadeh, Fahimeh
collection PubMed
description INTRODUCTION: Oral lichen planus (OLP) is a chronic mucocutaneous disease. It is mainly an immune system-related disorder. Vitamins can modulate immune system functions, and thus, vitamin deficiency might have roles in exacerbating OLP. We aim to determine the serum levels of vitamins A, B12, C, D3, and E in OLP patients. METHODS AND MATERIALS: 34 OLP patients referred to Shiraz Dental School entered the study. Blood samples were collected and levels of A, B12, C, D3, and E vitamins were measured in serum. 43 healthy people were also included as the control group. Serum levels of vitamins were measured by HPLC (A, B12, D3, and E) and Kiazist analyzing kit (vitamin C). RESULTS: Most of the patients were female (62.3%), and the mean age of patients was 48.03 ± 11.57. Serum levels of vitamins A, C, and E were lower in OLP patients in comparison with the healthy group; however, the difference was not significant. Vitamins B12 and D3 were higher in the OLP group but the difference was not significant. CONCLUSION: Serum levels of vitamins A, B12, C, D3, and E do not have a significant difference in OLP patients and healthy groups. These vitamins may not have a considerable role in OLP pathogenesis in the southwest of Iran.
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spelling pubmed-79327762021-03-10 Serum Vitamin Profile in Oral Lichen Planus Patients in Southwest of Iran Rezazadeh, Fahimeh Haghighat, Sara Biomed Res Int Research Article INTRODUCTION: Oral lichen planus (OLP) is a chronic mucocutaneous disease. It is mainly an immune system-related disorder. Vitamins can modulate immune system functions, and thus, vitamin deficiency might have roles in exacerbating OLP. We aim to determine the serum levels of vitamins A, B12, C, D3, and E in OLP patients. METHODS AND MATERIALS: 34 OLP patients referred to Shiraz Dental School entered the study. Blood samples were collected and levels of A, B12, C, D3, and E vitamins were measured in serum. 43 healthy people were also included as the control group. Serum levels of vitamins were measured by HPLC (A, B12, D3, and E) and Kiazist analyzing kit (vitamin C). RESULTS: Most of the patients were female (62.3%), and the mean age of patients was 48.03 ± 11.57. Serum levels of vitamins A, C, and E were lower in OLP patients in comparison with the healthy group; however, the difference was not significant. Vitamins B12 and D3 were higher in the OLP group but the difference was not significant. CONCLUSION: Serum levels of vitamins A, B12, C, D3, and E do not have a significant difference in OLP patients and healthy groups. These vitamins may not have a considerable role in OLP pathogenesis in the southwest of Iran. Hindawi 2021-02-24 /pmc/articles/PMC7932776/ /pubmed/33708994 http://dx.doi.org/10.1155/2021/8627435 Text en Copyright © 2021 Fahimeh Rezazadeh and Sara Haghighat. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Rezazadeh, Fahimeh
Haghighat, Sara
Serum Vitamin Profile in Oral Lichen Planus Patients in Southwest of Iran
title Serum Vitamin Profile in Oral Lichen Planus Patients in Southwest of Iran
title_full Serum Vitamin Profile in Oral Lichen Planus Patients in Southwest of Iran
title_fullStr Serum Vitamin Profile in Oral Lichen Planus Patients in Southwest of Iran
title_full_unstemmed Serum Vitamin Profile in Oral Lichen Planus Patients in Southwest of Iran
title_short Serum Vitamin Profile in Oral Lichen Planus Patients in Southwest of Iran
title_sort serum vitamin profile in oral lichen planus patients in southwest of iran
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7932776/
https://www.ncbi.nlm.nih.gov/pubmed/33708994
http://dx.doi.org/10.1155/2021/8627435
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