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Chromothripsis drives the evolution of gene amplification in cancer
Focal chromosomal amplification is an important route to generating cancer through mediating over-expression of oncogenes(1–3) or to developing cancer therapy resistance by increasing expression of a gene whose action diminishes efficacy of an anti-cancer drug. Here we used whole-genome sequencing o...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933129/ https://www.ncbi.nlm.nih.gov/pubmed/33361815 http://dx.doi.org/10.1038/s41586-020-03064-z |