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Meta-analysis of grey matter changes and their behavioral characterization in patients with alcohol use disorder

Alcohol Use Disorder (AUD) is associated with reductions in grey matter (GM) volume which can lead to changes in numerous brain functions. The results of previous studies on altered GM in AUD differ considerably in the regions identified. Three meta-analyses carried out between 2014 and 2017 yielded...

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Autores principales: Spindler, Carolin, Trautmann, Sebastian, Alexander, Nina, Bröning, Sonja, Bartscher, Sarah, Stuppe, Markus, Muehlhan, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933165/
https://www.ncbi.nlm.nih.gov/pubmed/33664372
http://dx.doi.org/10.1038/s41598-021-84804-7
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author Spindler, Carolin
Trautmann, Sebastian
Alexander, Nina
Bröning, Sonja
Bartscher, Sarah
Stuppe, Markus
Muehlhan, Markus
author_facet Spindler, Carolin
Trautmann, Sebastian
Alexander, Nina
Bröning, Sonja
Bartscher, Sarah
Stuppe, Markus
Muehlhan, Markus
author_sort Spindler, Carolin
collection PubMed
description Alcohol Use Disorder (AUD) is associated with reductions in grey matter (GM) volume which can lead to changes in numerous brain functions. The results of previous studies on altered GM in AUD differ considerably in the regions identified. Three meta-analyses carried out between 2014 and 2017 yielded different results. The present study includes the considerable amount of newer research and delivers a state-of-the art meta-analysis in line with recently published guidelines. Additionally, we behaviorally characterized affected regions using fMRI metadata and identified related brain networks by determining their meta-analytic connectivity patterns. Twenty-seven studies with 1,045 AUD patients and 1,054 healthy controls were included in the analysis and analyzed by means of Anatomical Likelihood Estimation (ALE). GM alterations were identified in eight clusters covering different parts of the cingulate and medial frontal gyri, paracentral lobes, left post- and precentral gyri, left anterior and right posterior insulae and left superior frontal gyrus. The behavioral characterization associated these regions with specific cognitive, emotional, somatosensory and motor functions. Moreover, the clusters represent nodes within behaviorally relevant brain networks. Our results suggest that GM reduction in AUD could disrupt network communication responsible for the neurocognitive impairments associated with high chronic alcohol consumption.
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spelling pubmed-79331652021-03-05 Meta-analysis of grey matter changes and their behavioral characterization in patients with alcohol use disorder Spindler, Carolin Trautmann, Sebastian Alexander, Nina Bröning, Sonja Bartscher, Sarah Stuppe, Markus Muehlhan, Markus Sci Rep Article Alcohol Use Disorder (AUD) is associated with reductions in grey matter (GM) volume which can lead to changes in numerous brain functions. The results of previous studies on altered GM in AUD differ considerably in the regions identified. Three meta-analyses carried out between 2014 and 2017 yielded different results. The present study includes the considerable amount of newer research and delivers a state-of-the art meta-analysis in line with recently published guidelines. Additionally, we behaviorally characterized affected regions using fMRI metadata and identified related brain networks by determining their meta-analytic connectivity patterns. Twenty-seven studies with 1,045 AUD patients and 1,054 healthy controls were included in the analysis and analyzed by means of Anatomical Likelihood Estimation (ALE). GM alterations were identified in eight clusters covering different parts of the cingulate and medial frontal gyri, paracentral lobes, left post- and precentral gyri, left anterior and right posterior insulae and left superior frontal gyrus. The behavioral characterization associated these regions with specific cognitive, emotional, somatosensory and motor functions. Moreover, the clusters represent nodes within behaviorally relevant brain networks. Our results suggest that GM reduction in AUD could disrupt network communication responsible for the neurocognitive impairments associated with high chronic alcohol consumption. Nature Publishing Group UK 2021-03-04 /pmc/articles/PMC7933165/ /pubmed/33664372 http://dx.doi.org/10.1038/s41598-021-84804-7 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Spindler, Carolin
Trautmann, Sebastian
Alexander, Nina
Bröning, Sonja
Bartscher, Sarah
Stuppe, Markus
Muehlhan, Markus
Meta-analysis of grey matter changes and their behavioral characterization in patients with alcohol use disorder
title Meta-analysis of grey matter changes and their behavioral characterization in patients with alcohol use disorder
title_full Meta-analysis of grey matter changes and their behavioral characterization in patients with alcohol use disorder
title_fullStr Meta-analysis of grey matter changes and their behavioral characterization in patients with alcohol use disorder
title_full_unstemmed Meta-analysis of grey matter changes and their behavioral characterization in patients with alcohol use disorder
title_short Meta-analysis of grey matter changes and their behavioral characterization in patients with alcohol use disorder
title_sort meta-analysis of grey matter changes and their behavioral characterization in patients with alcohol use disorder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933165/
https://www.ncbi.nlm.nih.gov/pubmed/33664372
http://dx.doi.org/10.1038/s41598-021-84804-7
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