Effects of Berberine on the Gastrointestinal Microbiota

The gastrointestinal microbiota is a multi-faceted system that is unraveling novel contributors to the development and progression of several diseases. Berberine has been used to treat obesity, diabetes mellitus, atherosclerosis, and metabolic diseases in China. There are also clinical trials regard...

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Autores principales: Zhang, Lichao, Wu, Xiaoying, Yang, Ruibing, Chen, Fang, Liao, Yao, Zhu, Zifeng, Wu, Zhongdao, Sun, Xi, Wang, Lifu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933196/
https://www.ncbi.nlm.nih.gov/pubmed/33680978
http://dx.doi.org/10.3389/fcimb.2020.588517
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author Zhang, Lichao
Wu, Xiaoying
Yang, Ruibing
Chen, Fang
Liao, Yao
Zhu, Zifeng
Wu, Zhongdao
Sun, Xi
Wang, Lifu
author_facet Zhang, Lichao
Wu, Xiaoying
Yang, Ruibing
Chen, Fang
Liao, Yao
Zhu, Zifeng
Wu, Zhongdao
Sun, Xi
Wang, Lifu
author_sort Zhang, Lichao
collection PubMed
description The gastrointestinal microbiota is a multi-faceted system that is unraveling novel contributors to the development and progression of several diseases. Berberine has been used to treat obesity, diabetes mellitus, atherosclerosis, and metabolic diseases in China. There are also clinical trials regarding berberine use in cardiovascular, gastrointestinal, and endocrine diseases. Berberine elicits clinical benefits at standard doses and has low toxicity. The mechanism underlying the role of berberine in lipid‐lowering and insulin resistance is incompletely understood, but one of the possible mechanisms is related to its effect on the gastrointestinal microbiota. An extensive search in electronic databases (PubMed, Scopus, Embase, Web of Sciences, Science Direct) was used to identify the role of the gastrointestinal microbiota in the berberine treatment. The aim of this review was to summarize the pharmacologic effects of berberine on animals and humans by regulation of the gastrointestinal microbiota.
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spelling pubmed-79331962021-03-06 Effects of Berberine on the Gastrointestinal Microbiota Zhang, Lichao Wu, Xiaoying Yang, Ruibing Chen, Fang Liao, Yao Zhu, Zifeng Wu, Zhongdao Sun, Xi Wang, Lifu Front Cell Infect Microbiol Cellular and Infection Microbiology The gastrointestinal microbiota is a multi-faceted system that is unraveling novel contributors to the development and progression of several diseases. Berberine has been used to treat obesity, diabetes mellitus, atherosclerosis, and metabolic diseases in China. There are also clinical trials regarding berberine use in cardiovascular, gastrointestinal, and endocrine diseases. Berberine elicits clinical benefits at standard doses and has low toxicity. The mechanism underlying the role of berberine in lipid‐lowering and insulin resistance is incompletely understood, but one of the possible mechanisms is related to its effect on the gastrointestinal microbiota. An extensive search in electronic databases (PubMed, Scopus, Embase, Web of Sciences, Science Direct) was used to identify the role of the gastrointestinal microbiota in the berberine treatment. The aim of this review was to summarize the pharmacologic effects of berberine on animals and humans by regulation of the gastrointestinal microbiota. Frontiers Media S.A. 2021-02-19 /pmc/articles/PMC7933196/ /pubmed/33680978 http://dx.doi.org/10.3389/fcimb.2020.588517 Text en Copyright © 2021 Zhang, Wu, Yang, Chen, Liao, Zhu, Wu, Sun and Wang http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Zhang, Lichao
Wu, Xiaoying
Yang, Ruibing
Chen, Fang
Liao, Yao
Zhu, Zifeng
Wu, Zhongdao
Sun, Xi
Wang, Lifu
Effects of Berberine on the Gastrointestinal Microbiota
title Effects of Berberine on the Gastrointestinal Microbiota
title_full Effects of Berberine on the Gastrointestinal Microbiota
title_fullStr Effects of Berberine on the Gastrointestinal Microbiota
title_full_unstemmed Effects of Berberine on the Gastrointestinal Microbiota
title_short Effects of Berberine on the Gastrointestinal Microbiota
title_sort effects of berberine on the gastrointestinal microbiota
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933196/
https://www.ncbi.nlm.nih.gov/pubmed/33680978
http://dx.doi.org/10.3389/fcimb.2020.588517
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