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The Effects of 0.01% Atropine on Adult Myopes’ Contrast Sensitivity
PURPOSE: Atropine at a low concentration is considered a safe and effective treatment to mitigate myopia progression. However, the potential unwanted side effects of administering atropine at a low dose on visual functions other than best corrected visual acuity has not been investigated. In this st...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933202/ https://www.ncbi.nlm.nih.gov/pubmed/33679306 http://dx.doi.org/10.3389/fnins.2021.624472 |
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author | Cheng, Ziyun Mei, Jianhui Cao, Suqi Zhang, Ran Zhou, Jiawei Wang, Yuwen |
author_facet | Cheng, Ziyun Mei, Jianhui Cao, Suqi Zhang, Ran Zhou, Jiawei Wang, Yuwen |
author_sort | Cheng, Ziyun |
collection | PubMed |
description | PURPOSE: Atropine at a low concentration is considered a safe and effective treatment to mitigate myopia progression. However, the potential unwanted side effects of administering atropine at a low dose on visual functions other than best corrected visual acuity has not been investigated. In this study, we investigate the short-term (12,16, and 20 h) and long-term (1, 2, and 4 weeks) effects of 0.01% atropine (i.e., 0.1 mg/ml) on contrast sensitivity (CS) in patients with myopia. METHODS: Thirty adults (23.33 ± 2.93 years old) with myopia between -1.00 and -6.00 diopters (D), astigmatism of -1.50 D or less, and anisometropia of 1.00 D or less, participated in this prospective, masked, placebo-controlled, randomized study. The participants were randomly assigned to receive 0.01% atropine or polyvinyl alcohol eye drops once nightly to both eyes for four weeks. CS was measured binocularly at baseline and 12, 16, 20 h, 1, 2, and 4 weeks after the first use of the eye drops. RESULTS: There was no statistically significant differences of CS found between atropine and placebo-controlled groups in both short-term and long-term. There was no statistically significant interaction effect found between the time and group. CONCLUSION: We demonstrated no significant deleterious effect of 0.01% atropine on adult myopes’ CS. |
format | Online Article Text |
id | pubmed-7933202 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79332022021-03-06 The Effects of 0.01% Atropine on Adult Myopes’ Contrast Sensitivity Cheng, Ziyun Mei, Jianhui Cao, Suqi Zhang, Ran Zhou, Jiawei Wang, Yuwen Front Neurosci Neuroscience PURPOSE: Atropine at a low concentration is considered a safe and effective treatment to mitigate myopia progression. However, the potential unwanted side effects of administering atropine at a low dose on visual functions other than best corrected visual acuity has not been investigated. In this study, we investigate the short-term (12,16, and 20 h) and long-term (1, 2, and 4 weeks) effects of 0.01% atropine (i.e., 0.1 mg/ml) on contrast sensitivity (CS) in patients with myopia. METHODS: Thirty adults (23.33 ± 2.93 years old) with myopia between -1.00 and -6.00 diopters (D), astigmatism of -1.50 D or less, and anisometropia of 1.00 D or less, participated in this prospective, masked, placebo-controlled, randomized study. The participants were randomly assigned to receive 0.01% atropine or polyvinyl alcohol eye drops once nightly to both eyes for four weeks. CS was measured binocularly at baseline and 12, 16, 20 h, 1, 2, and 4 weeks after the first use of the eye drops. RESULTS: There was no statistically significant differences of CS found between atropine and placebo-controlled groups in both short-term and long-term. There was no statistically significant interaction effect found between the time and group. CONCLUSION: We demonstrated no significant deleterious effect of 0.01% atropine on adult myopes’ CS. Frontiers Media S.A. 2021-02-19 /pmc/articles/PMC7933202/ /pubmed/33679306 http://dx.doi.org/10.3389/fnins.2021.624472 Text en Copyright © 2021 Cheng, Mei, Cao, Zhang, Zhou and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Cheng, Ziyun Mei, Jianhui Cao, Suqi Zhang, Ran Zhou, Jiawei Wang, Yuwen The Effects of 0.01% Atropine on Adult Myopes’ Contrast Sensitivity |
title | The Effects of 0.01% Atropine on Adult Myopes’ Contrast Sensitivity |
title_full | The Effects of 0.01% Atropine on Adult Myopes’ Contrast Sensitivity |
title_fullStr | The Effects of 0.01% Atropine on Adult Myopes’ Contrast Sensitivity |
title_full_unstemmed | The Effects of 0.01% Atropine on Adult Myopes’ Contrast Sensitivity |
title_short | The Effects of 0.01% Atropine on Adult Myopes’ Contrast Sensitivity |
title_sort | effects of 0.01% atropine on adult myopes’ contrast sensitivity |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933202/ https://www.ncbi.nlm.nih.gov/pubmed/33679306 http://dx.doi.org/10.3389/fnins.2021.624472 |
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