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Case Report: Early-Onset Guillain–Barre Syndrome Mimicking Stroke
Introduction: Guillain–Barre syndrome (GBS) is an acute immune-mediated inflammatory demyelinating polyneuropathy characterized by symmetrical limb weakness and areflexia. GBS can have different clinical manifestations; hence, the initial symptoms are also varied. Here, we describe a rare case of GB...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933233/ https://www.ncbi.nlm.nih.gov/pubmed/33679573 http://dx.doi.org/10.3389/fneur.2021.525699 |
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author | Sun, Jing Gao, Yu Chi, Lumei Cao, Qingyang Ning, Zhijie Nan, Guangxian |
author_facet | Sun, Jing Gao, Yu Chi, Lumei Cao, Qingyang Ning, Zhijie Nan, Guangxian |
author_sort | Sun, Jing |
collection | PubMed |
description | Introduction: Guillain–Barre syndrome (GBS) is an acute immune-mediated inflammatory demyelinating polyneuropathy characterized by symmetrical limb weakness and areflexia. GBS can have different clinical manifestations; hence, the initial symptoms are also varied. Here, we describe a rare case of GBS presenting as hemiparesis and cranial nerve palsy, which mimic brainstem stroke. Case Presentation: A 53-year-old man was admitted to the hospital with a 3-h history of left-arm weakness, glossolalia, and right eyelid droop. After admission, his condition suddenly worsened, with quadriplegia, bilateral peripheral facial palsy, bilateral ophthalmoplegia, and other neurological symptoms. Based on the findings from a neurological examination, MRI, cerebrospinal fluid analysis, and nerve conduction study, a diagnosis of GBS was made. He received intravenous immunoglobulin (0.4 kg/day) for 5 days. After 20 days of systematic therapy, his dysphagia, dyspnea, facial paralysis, ocular movement disorder, and leg weakness recovered almost completely, but his arms were still moderately impaired, with a power of 4/5. Fortunately, the patient recovered well without any sequelae after 2 years of follow-up. Conclusions: In patients with an atypical presentation, the diagnosis of GBS is often delayed. With this case report, we intend to highlight the fact that some symptoms mimicking stroke may be a feature of GBS at onset; close observation and timely diagnosis are crucial for clinicians. Neuroimaging is a valuable diagnostic tool in differentiating stroke from GBS. |
format | Online Article Text |
id | pubmed-7933233 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79332332021-03-06 Case Report: Early-Onset Guillain–Barre Syndrome Mimicking Stroke Sun, Jing Gao, Yu Chi, Lumei Cao, Qingyang Ning, Zhijie Nan, Guangxian Front Neurol Neurology Introduction: Guillain–Barre syndrome (GBS) is an acute immune-mediated inflammatory demyelinating polyneuropathy characterized by symmetrical limb weakness and areflexia. GBS can have different clinical manifestations; hence, the initial symptoms are also varied. Here, we describe a rare case of GBS presenting as hemiparesis and cranial nerve palsy, which mimic brainstem stroke. Case Presentation: A 53-year-old man was admitted to the hospital with a 3-h history of left-arm weakness, glossolalia, and right eyelid droop. After admission, his condition suddenly worsened, with quadriplegia, bilateral peripheral facial palsy, bilateral ophthalmoplegia, and other neurological symptoms. Based on the findings from a neurological examination, MRI, cerebrospinal fluid analysis, and nerve conduction study, a diagnosis of GBS was made. He received intravenous immunoglobulin (0.4 kg/day) for 5 days. After 20 days of systematic therapy, his dysphagia, dyspnea, facial paralysis, ocular movement disorder, and leg weakness recovered almost completely, but his arms were still moderately impaired, with a power of 4/5. Fortunately, the patient recovered well without any sequelae after 2 years of follow-up. Conclusions: In patients with an atypical presentation, the diagnosis of GBS is often delayed. With this case report, we intend to highlight the fact that some symptoms mimicking stroke may be a feature of GBS at onset; close observation and timely diagnosis are crucial for clinicians. Neuroimaging is a valuable diagnostic tool in differentiating stroke from GBS. Frontiers Media S.A. 2021-02-19 /pmc/articles/PMC7933233/ /pubmed/33679573 http://dx.doi.org/10.3389/fneur.2021.525699 Text en Copyright © 2021 Sun, Gao, Chi, Cao, Ning and Nan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Sun, Jing Gao, Yu Chi, Lumei Cao, Qingyang Ning, Zhijie Nan, Guangxian Case Report: Early-Onset Guillain–Barre Syndrome Mimicking Stroke |
title | Case Report: Early-Onset Guillain–Barre Syndrome Mimicking Stroke |
title_full | Case Report: Early-Onset Guillain–Barre Syndrome Mimicking Stroke |
title_fullStr | Case Report: Early-Onset Guillain–Barre Syndrome Mimicking Stroke |
title_full_unstemmed | Case Report: Early-Onset Guillain–Barre Syndrome Mimicking Stroke |
title_short | Case Report: Early-Onset Guillain–Barre Syndrome Mimicking Stroke |
title_sort | case report: early-onset guillain–barre syndrome mimicking stroke |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933233/ https://www.ncbi.nlm.nih.gov/pubmed/33679573 http://dx.doi.org/10.3389/fneur.2021.525699 |
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