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Chromosomal translocation t(11;14) and p53 deletion induced by the CRISPR/Cas9 system in normal B cell-derived iPS cells

Multiple myeloma (MM) cells are derived from mature B cells based on immunoglobulin heavy chain (IgH) gene analysis. The onset of MM is often caused by a reciprocal chromosomal translocation (cTr) between chr 14 with IgH and chr 11 with CCND1. We propose that mature B cells gain potential to transfo...

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Detalles Bibliográficos
Autores principales:	Azami, Yusuke, Tsuyama, Naohiro, Abe, Yu, Sugai-Takahashi, Misaki, Kudo, Ken-ichi, Ota, Akinobu, Sivasundaram, Karnan, Muramatsu, Moe, Shigemura, Tomonari, Sasatani, Megumi, Hashimoto, Yuko, Saji, Shigehira, Kamiya, Kenji, Hanamura, Ichiro, Ikezoe, Takayuki, Onodera, Masafumi, Sakai, Akira
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933289/ https://www.ncbi.nlm.nih.gov/pubmed/33664418 http://dx.doi.org/10.1038/s41598-021-84628-5

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