On the Famous Traditional Chinese Medicine “Fu Zi”: Discovery, Research, and Development of Cardioactive Constituent Mesaconine

ABSTRACT: This review summarizes the process of the discovery, research, and development of a cardioactive component, mesaconine, from the lateral roots of Aconitum carmichaelii (“Fu Zi”). To date, pre-clinical showed that mesaconine is a novel type of cardiotonic lead drug with relatively high pote...

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Autores principales: Wang, Feng-Peng, Chao, Ruo-Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933290/
https://www.ncbi.nlm.nih.gov/pubmed/32960403
http://dx.doi.org/10.1007/s13659-020-00266-w
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author Wang, Feng-Peng
Chao, Ruo-Bing
author_facet Wang, Feng-Peng
Chao, Ruo-Bing
author_sort Wang, Feng-Peng
collection PubMed
description ABSTRACT: This review summarizes the process of the discovery, research, and development of a cardioactive component, mesaconine, from the lateral roots of Aconitum carmichaelii (“Fu Zi”). To date, pre-clinical showed that mesaconine is a novel type of cardiotonic lead drug with relatively high potency, low toxicity, and a new mechanism. GRAPHIC ABSTRACT: [Image: see text]
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spelling pubmed-79332902021-03-19 On the Famous Traditional Chinese Medicine “Fu Zi”: Discovery, Research, and Development of Cardioactive Constituent Mesaconine Wang, Feng-Peng Chao, Ruo-Bing Nat Prod Bioprospect Review ABSTRACT: This review summarizes the process of the discovery, research, and development of a cardioactive component, mesaconine, from the lateral roots of Aconitum carmichaelii (“Fu Zi”). To date, pre-clinical showed that mesaconine is a novel type of cardiotonic lead drug with relatively high potency, low toxicity, and a new mechanism. GRAPHIC ABSTRACT: [Image: see text] Springer Singapore 2020-09-22 /pmc/articles/PMC7933290/ /pubmed/32960403 http://dx.doi.org/10.1007/s13659-020-00266-w Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Wang, Feng-Peng
Chao, Ruo-Bing
On the Famous Traditional Chinese Medicine “Fu Zi”: Discovery, Research, and Development of Cardioactive Constituent Mesaconine
title On the Famous Traditional Chinese Medicine “Fu Zi”: Discovery, Research, and Development of Cardioactive Constituent Mesaconine
title_full On the Famous Traditional Chinese Medicine “Fu Zi”: Discovery, Research, and Development of Cardioactive Constituent Mesaconine
title_fullStr On the Famous Traditional Chinese Medicine “Fu Zi”: Discovery, Research, and Development of Cardioactive Constituent Mesaconine
title_full_unstemmed On the Famous Traditional Chinese Medicine “Fu Zi”: Discovery, Research, and Development of Cardioactive Constituent Mesaconine
title_short On the Famous Traditional Chinese Medicine “Fu Zi”: Discovery, Research, and Development of Cardioactive Constituent Mesaconine
title_sort on the famous traditional chinese medicine “fu zi”: discovery, research, and development of cardioactive constituent mesaconine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933290/
https://www.ncbi.nlm.nih.gov/pubmed/32960403
http://dx.doi.org/10.1007/s13659-020-00266-w
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