Two New Quinazoline Derivatives from the Moss Endophytic Fungus Aspergillus sp. and Their Anti-inflammatory Activity

ABSTRACT: Two new quinazoline derivatives versicomides E (1) and F (2), and 10 known compounds (3–12) were isolated from the moss endophytic fungus Aspergillus sp. Their structures were determined on the basis of extensive spectroscopic data analysis and ECD calculations. Among them, the compound 7...

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Autores principales: Wang, Ning-Ning, Liu, Chun-Yu, Wang, Tian, Li, Yue-Lan, Xu, Ke, Lou, Hong-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933300/
https://www.ncbi.nlm.nih.gov/pubmed/33219498
http://dx.doi.org/10.1007/s13659-020-00287-5
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author Wang, Ning-Ning
Liu, Chun-Yu
Wang, Tian
Li, Yue-Lan
Xu, Ke
Lou, Hong-Xiang
author_facet Wang, Ning-Ning
Liu, Chun-Yu
Wang, Tian
Li, Yue-Lan
Xu, Ke
Lou, Hong-Xiang
author_sort Wang, Ning-Ning
collection PubMed
description ABSTRACT: Two new quinazoline derivatives versicomides E (1) and F (2), and 10 known compounds (3–12) were isolated from the moss endophytic fungus Aspergillus sp. Their structures were determined on the basis of extensive spectroscopic data analysis and ECD calculations. Among them, the compound 7 (6-hydroxy-3-methoxyviridicatin) was first reported as a natural product. Inhibition on LPS-induced NO production in RAW 264.7 murine macrophages found that compounds 5, 7 and 8 showed significant inhibitory effects on NO production, with IC(50) values of 49.85, 22.14 and 46.02 μM respectively. GRAPHIC ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-020-00287-5) contains supplementary material, which is available to authorized users.
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spelling pubmed-79333002021-03-19 Two New Quinazoline Derivatives from the Moss Endophytic Fungus Aspergillus sp. and Their Anti-inflammatory Activity Wang, Ning-Ning Liu, Chun-Yu Wang, Tian Li, Yue-Lan Xu, Ke Lou, Hong-Xiang Nat Prod Bioprospect Original Article ABSTRACT: Two new quinazoline derivatives versicomides E (1) and F (2), and 10 known compounds (3–12) were isolated from the moss endophytic fungus Aspergillus sp. Their structures were determined on the basis of extensive spectroscopic data analysis and ECD calculations. Among them, the compound 7 (6-hydroxy-3-methoxyviridicatin) was first reported as a natural product. Inhibition on LPS-induced NO production in RAW 264.7 murine macrophages found that compounds 5, 7 and 8 showed significant inhibitory effects on NO production, with IC(50) values of 49.85, 22.14 and 46.02 μM respectively. GRAPHIC ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-020-00287-5) contains supplementary material, which is available to authorized users. Springer Singapore 2020-11-21 /pmc/articles/PMC7933300/ /pubmed/33219498 http://dx.doi.org/10.1007/s13659-020-00287-5 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article
Wang, Ning-Ning
Liu, Chun-Yu
Wang, Tian
Li, Yue-Lan
Xu, Ke
Lou, Hong-Xiang
Two New Quinazoline Derivatives from the Moss Endophytic Fungus Aspergillus sp. and Their Anti-inflammatory Activity
title Two New Quinazoline Derivatives from the Moss Endophytic Fungus Aspergillus sp. and Their Anti-inflammatory Activity
title_full Two New Quinazoline Derivatives from the Moss Endophytic Fungus Aspergillus sp. and Their Anti-inflammatory Activity
title_fullStr Two New Quinazoline Derivatives from the Moss Endophytic Fungus Aspergillus sp. and Their Anti-inflammatory Activity
title_full_unstemmed Two New Quinazoline Derivatives from the Moss Endophytic Fungus Aspergillus sp. and Their Anti-inflammatory Activity
title_short Two New Quinazoline Derivatives from the Moss Endophytic Fungus Aspergillus sp. and Their Anti-inflammatory Activity
title_sort two new quinazoline derivatives from the moss endophytic fungus aspergillus sp. and their anti-inflammatory activity
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933300/
https://www.ncbi.nlm.nih.gov/pubmed/33219498
http://dx.doi.org/10.1007/s13659-020-00287-5
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