Four New Limonoids from the Barks of Toona ciliata

ABSTRACT: Four new limonoids, toonayunnanaes F − I (1 − 4), and six known compounds (5 − 10) were isolated from the barks of Toona ciliata. Their structures were elucidated by thoroughly analyzing of NMR and HRMS data, and single-crystal X-ray diffraction of 1. The oxetane ring moiety in 1 was rare...

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Detalles Bibliográficos
Autores principales: Zhang, Pan-Pan, Bu, Yun-Ge, Xue, Shang, Cui, Zhi-Rong, Tang, Peng-Fei, Luo, Jun, Kong, Ling-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933302/
https://www.ncbi.nlm.nih.gov/pubmed/33098068
http://dx.doi.org/10.1007/s13659-020-00274-w
Descripción
Sumario:ABSTRACT: Four new limonoids, toonayunnanaes F − I (1 − 4), and six known compounds (5 − 10) were isolated from the barks of Toona ciliata. Their structures were elucidated by thoroughly analyzing of NMR and HRMS data, and single-crystal X-ray diffraction of 1. The oxetane ring moiety in 1 was rare in limonoids and other natural products. Compound 1 showed nitric oxide (NO) inhibitory effect with an IC(50) 38.45 ± 0.41 µM in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages. GRAPHIC ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-020-00274-w) contains supplementary material, which is available to authorized users.

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