Four New Limonoids from the Barks of Toona ciliata

ABSTRACT: Four new limonoids, toonayunnanaes F − I (1 − 4), and six known compounds (5 − 10) were isolated from the barks of Toona ciliata. Their structures were elucidated by thoroughly analyzing of NMR and HRMS data, and single-crystal X-ray diffraction of 1. The oxetane ring moiety in 1 was rare...

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Autores principales: Zhang, Pan-Pan, Bu, Yun-Ge, Xue, Shang, Cui, Zhi-Rong, Tang, Peng-Fei, Luo, Jun, Kong, Ling-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933302/
https://www.ncbi.nlm.nih.gov/pubmed/33098068
http://dx.doi.org/10.1007/s13659-020-00274-w
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author Zhang, Pan-Pan
Bu, Yun-Ge
Xue, Shang
Cui, Zhi-Rong
Tang, Peng-Fei
Luo, Jun
Kong, Ling-Yi
author_facet Zhang, Pan-Pan
Bu, Yun-Ge
Xue, Shang
Cui, Zhi-Rong
Tang, Peng-Fei
Luo, Jun
Kong, Ling-Yi
author_sort Zhang, Pan-Pan
collection PubMed
description ABSTRACT: Four new limonoids, toonayunnanaes F − I (1 − 4), and six known compounds (5 − 10) were isolated from the barks of Toona ciliata. Their structures were elucidated by thoroughly analyzing of NMR and HRMS data, and single-crystal X-ray diffraction of 1. The oxetane ring moiety in 1 was rare in limonoids and other natural products. Compound 1 showed nitric oxide (NO) inhibitory effect with an IC(50) 38.45 ± 0.41 µM in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages. GRAPHIC ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-020-00274-w) contains supplementary material, which is available to authorized users.
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spelling pubmed-79333022021-03-19 Four New Limonoids from the Barks of Toona ciliata Zhang, Pan-Pan Bu, Yun-Ge Xue, Shang Cui, Zhi-Rong Tang, Peng-Fei Luo, Jun Kong, Ling-Yi Nat Prod Bioprospect Original Article ABSTRACT: Four new limonoids, toonayunnanaes F − I (1 − 4), and six known compounds (5 − 10) were isolated from the barks of Toona ciliata. Their structures were elucidated by thoroughly analyzing of NMR and HRMS data, and single-crystal X-ray diffraction of 1. The oxetane ring moiety in 1 was rare in limonoids and other natural products. Compound 1 showed nitric oxide (NO) inhibitory effect with an IC(50) 38.45 ± 0.41 µM in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages. GRAPHIC ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-020-00274-w) contains supplementary material, which is available to authorized users. Springer Singapore 2020-10-23 /pmc/articles/PMC7933302/ /pubmed/33098068 http://dx.doi.org/10.1007/s13659-020-00274-w Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article
Zhang, Pan-Pan
Bu, Yun-Ge
Xue, Shang
Cui, Zhi-Rong
Tang, Peng-Fei
Luo, Jun
Kong, Ling-Yi
Four New Limonoids from the Barks of Toona ciliata
title Four New Limonoids from the Barks of Toona ciliata
title_full Four New Limonoids from the Barks of Toona ciliata
title_fullStr Four New Limonoids from the Barks of Toona ciliata
title_full_unstemmed Four New Limonoids from the Barks of Toona ciliata
title_short Four New Limonoids from the Barks of Toona ciliata
title_sort four new limonoids from the barks of toona ciliata
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933302/
https://www.ncbi.nlm.nih.gov/pubmed/33098068
http://dx.doi.org/10.1007/s13659-020-00274-w
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