Neolignans and Norlignans from Insect Medicine Polyphaga plancyi and Their Biological Activities

ABSTRACT: Ten neolignans or norlignans (1–10) including eight new compounds were isolated from the whole bodies of Polyphaga plancyi Bolivar. Their structures were identified by spectroscopic data. Compounds 3, 4, 8, and 9 are racemates indicated by chiral HPLC analysis. Chiral separation followed b...

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Detalles Bibliográficos
Autores principales: Zhu, Hong-Jie, Xu, Te, Yan, Yong-Ming, Tu, Zheng-Chao, Cheng, Yong-Xian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933325/
https://www.ncbi.nlm.nih.gov/pubmed/32876846
http://dx.doi.org/10.1007/s13659-020-00262-0
Descripción
Sumario:ABSTRACT: Ten neolignans or norlignans (1–10) including eight new compounds were isolated from the whole bodies of Polyphaga plancyi Bolivar. Their structures were identified by spectroscopic data. Compounds 3, 4, 8, and 9 are racemates indicated by chiral HPLC analysis. Chiral separation followed by ECD calculations allowed to clarify the absolute configurations of all the antipodes. All the new compounds were evaluated for their biological properties toward extracellular matrix in rat renal proximal tubular cells, human cancer cells (K562, A549, and Huh7), EV71, ROCK2, JAK3, DDR1, and coagulation. GRAPHIC ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-020-00262-0) contains supplementary material, which is available to authorized users.

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