Neolignans and Norlignans from Insect Medicine Polyphaga plancyi and Their Biological Activities

ABSTRACT: Ten neolignans or norlignans (1–10) including eight new compounds were isolated from the whole bodies of Polyphaga plancyi Bolivar. Their structures were identified by spectroscopic data. Compounds 3, 4, 8, and 9 are racemates indicated by chiral HPLC analysis. Chiral separation followed b...

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Autores principales: Zhu, Hong-Jie, Xu, Te, Yan, Yong-Ming, Tu, Zheng-Chao, Cheng, Yong-Xian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933325/
https://www.ncbi.nlm.nih.gov/pubmed/32876846
http://dx.doi.org/10.1007/s13659-020-00262-0
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author Zhu, Hong-Jie
Xu, Te
Yan, Yong-Ming
Tu, Zheng-Chao
Cheng, Yong-Xian
author_facet Zhu, Hong-Jie
Xu, Te
Yan, Yong-Ming
Tu, Zheng-Chao
Cheng, Yong-Xian
author_sort Zhu, Hong-Jie
collection PubMed
description ABSTRACT: Ten neolignans or norlignans (1–10) including eight new compounds were isolated from the whole bodies of Polyphaga plancyi Bolivar. Their structures were identified by spectroscopic data. Compounds 3, 4, 8, and 9 are racemates indicated by chiral HPLC analysis. Chiral separation followed by ECD calculations allowed to clarify the absolute configurations of all the antipodes. All the new compounds were evaluated for their biological properties toward extracellular matrix in rat renal proximal tubular cells, human cancer cells (K562, A549, and Huh7), EV71, ROCK2, JAK3, DDR1, and coagulation. GRAPHIC ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-020-00262-0) contains supplementary material, which is available to authorized users.
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spelling pubmed-79333252021-03-19 Neolignans and Norlignans from Insect Medicine Polyphaga plancyi and Their Biological Activities Zhu, Hong-Jie Xu, Te Yan, Yong-Ming Tu, Zheng-Chao Cheng, Yong-Xian Nat Prod Bioprospect Original Article ABSTRACT: Ten neolignans or norlignans (1–10) including eight new compounds were isolated from the whole bodies of Polyphaga plancyi Bolivar. Their structures were identified by spectroscopic data. Compounds 3, 4, 8, and 9 are racemates indicated by chiral HPLC analysis. Chiral separation followed by ECD calculations allowed to clarify the absolute configurations of all the antipodes. All the new compounds were evaluated for their biological properties toward extracellular matrix in rat renal proximal tubular cells, human cancer cells (K562, A549, and Huh7), EV71, ROCK2, JAK3, DDR1, and coagulation. GRAPHIC ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-020-00262-0) contains supplementary material, which is available to authorized users. Springer Singapore 2020-09-02 /pmc/articles/PMC7933325/ /pubmed/32876846 http://dx.doi.org/10.1007/s13659-020-00262-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article
Zhu, Hong-Jie
Xu, Te
Yan, Yong-Ming
Tu, Zheng-Chao
Cheng, Yong-Xian
Neolignans and Norlignans from Insect Medicine Polyphaga plancyi and Their Biological Activities
title Neolignans and Norlignans from Insect Medicine Polyphaga plancyi and Their Biological Activities
title_full Neolignans and Norlignans from Insect Medicine Polyphaga plancyi and Their Biological Activities
title_fullStr Neolignans and Norlignans from Insect Medicine Polyphaga plancyi and Their Biological Activities
title_full_unstemmed Neolignans and Norlignans from Insect Medicine Polyphaga plancyi and Their Biological Activities
title_short Neolignans and Norlignans from Insect Medicine Polyphaga plancyi and Their Biological Activities
title_sort neolignans and norlignans from insect medicine polyphaga plancyi and their biological activities
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933325/
https://www.ncbi.nlm.nih.gov/pubmed/32876846
http://dx.doi.org/10.1007/s13659-020-00262-0
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