Lagerindicine, a New Pyrrole Alkaloid Isolated from the Flowers of Lagerstroemia indica Linnaeus

ABSTRACT: A phytochemical investigation of the EtOH extract of the flowers of Lagerstroemia indica L. led to the isolation and characterization of a new pyrrole alkaloid, named lagerindicine (1), along with four known compounds (2–5). Their structures were elucidated by the detailed spectroscopic an...

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Detalles Bibliográficos
Autores principales: Chen, Yi, Li, Song-Wei, Yin, Fang-Zhou, Yang, Min, Huan, Xia-Juan, Miao, Ze-Hong, Wang, Xiao-Ming, Guo, Yue-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933331/
https://www.ncbi.nlm.nih.gov/pubmed/33083968
http://dx.doi.org/10.1007/s13659-020-00273-x
Descripción
Sumario:ABSTRACT: A phytochemical investigation of the EtOH extract of the flowers of Lagerstroemia indica L. led to the isolation and characterization of a new pyrrole alkaloid, named lagerindicine (1), along with four known compounds (2–5). Their structures were elucidated by the detailed spectroscopic analysis and comparison with literature data, whereas the structure, in particularly, the absolute configuration (AC) of 1, was firmly determined by total synthesis. All the isolates were evaluated for their cytotoxic effects against human colon cancer cell (HCT-116), and compound 3 exhibited weak cytotoxicity with IC(50) value of 28.4 μM. GRAPHIC ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-020-00273-x) contains supplementary material, which is available to authorized users.

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