Lagerindicine, a New Pyrrole Alkaloid Isolated from the Flowers of Lagerstroemia indica Linnaeus

ABSTRACT: A phytochemical investigation of the EtOH extract of the flowers of Lagerstroemia indica L. led to the isolation and characterization of a new pyrrole alkaloid, named lagerindicine (1), along with four known compounds (2–5). Their structures were elucidated by the detailed spectroscopic an...

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Autores principales: Chen, Yi, Li, Song-Wei, Yin, Fang-Zhou, Yang, Min, Huan, Xia-Juan, Miao, Ze-Hong, Wang, Xiao-Ming, Guo, Yue-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933331/
https://www.ncbi.nlm.nih.gov/pubmed/33083968
http://dx.doi.org/10.1007/s13659-020-00273-x
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author Chen, Yi
Li, Song-Wei
Yin, Fang-Zhou
Yang, Min
Huan, Xia-Juan
Miao, Ze-Hong
Wang, Xiao-Ming
Guo, Yue-Wei
author_facet Chen, Yi
Li, Song-Wei
Yin, Fang-Zhou
Yang, Min
Huan, Xia-Juan
Miao, Ze-Hong
Wang, Xiao-Ming
Guo, Yue-Wei
author_sort Chen, Yi
collection PubMed
description ABSTRACT: A phytochemical investigation of the EtOH extract of the flowers of Lagerstroemia indica L. led to the isolation and characterization of a new pyrrole alkaloid, named lagerindicine (1), along with four known compounds (2–5). Their structures were elucidated by the detailed spectroscopic analysis and comparison with literature data, whereas the structure, in particularly, the absolute configuration (AC) of 1, was firmly determined by total synthesis. All the isolates were evaluated for their cytotoxic effects against human colon cancer cell (HCT-116), and compound 3 exhibited weak cytotoxicity with IC(50) value of 28.4 μM. GRAPHIC ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-020-00273-x) contains supplementary material, which is available to authorized users.
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spelling pubmed-79333312021-03-19 Lagerindicine, a New Pyrrole Alkaloid Isolated from the Flowers of Lagerstroemia indica Linnaeus Chen, Yi Li, Song-Wei Yin, Fang-Zhou Yang, Min Huan, Xia-Juan Miao, Ze-Hong Wang, Xiao-Ming Guo, Yue-Wei Nat Prod Bioprospect Original Article ABSTRACT: A phytochemical investigation of the EtOH extract of the flowers of Lagerstroemia indica L. led to the isolation and characterization of a new pyrrole alkaloid, named lagerindicine (1), along with four known compounds (2–5). Their structures were elucidated by the detailed spectroscopic analysis and comparison with literature data, whereas the structure, in particularly, the absolute configuration (AC) of 1, was firmly determined by total synthesis. All the isolates were evaluated for their cytotoxic effects against human colon cancer cell (HCT-116), and compound 3 exhibited weak cytotoxicity with IC(50) value of 28.4 μM. GRAPHIC ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-020-00273-x) contains supplementary material, which is available to authorized users. Springer Singapore 2020-10-20 /pmc/articles/PMC7933331/ /pubmed/33083968 http://dx.doi.org/10.1007/s13659-020-00273-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article
Chen, Yi
Li, Song-Wei
Yin, Fang-Zhou
Yang, Min
Huan, Xia-Juan
Miao, Ze-Hong
Wang, Xiao-Ming
Guo, Yue-Wei
Lagerindicine, a New Pyrrole Alkaloid Isolated from the Flowers of Lagerstroemia indica Linnaeus
title Lagerindicine, a New Pyrrole Alkaloid Isolated from the Flowers of Lagerstroemia indica Linnaeus
title_full Lagerindicine, a New Pyrrole Alkaloid Isolated from the Flowers of Lagerstroemia indica Linnaeus
title_fullStr Lagerindicine, a New Pyrrole Alkaloid Isolated from the Flowers of Lagerstroemia indica Linnaeus
title_full_unstemmed Lagerindicine, a New Pyrrole Alkaloid Isolated from the Flowers of Lagerstroemia indica Linnaeus
title_short Lagerindicine, a New Pyrrole Alkaloid Isolated from the Flowers of Lagerstroemia indica Linnaeus
title_sort lagerindicine, a new pyrrole alkaloid isolated from the flowers of lagerstroemia indica linnaeus
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933331/
https://www.ncbi.nlm.nih.gov/pubmed/33083968
http://dx.doi.org/10.1007/s13659-020-00273-x
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