Will better evidence on clinical utility bring about greater use of (genetic) tests?

Greater clarity on the nature of clinical utility is desirable. Of itself it may not bring about greater use of tests, including WGS (whole-genome sequencing), not least because clinical utility studies when performed may not confirm predicted changes in patient outcome. The notion that single “pivo...

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Autor principal: Hyde, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933423/
https://www.ncbi.nlm.nih.gov/pubmed/33664270
http://dx.doi.org/10.1038/s41525-021-00187-8
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author Hyde, Chris
author_facet Hyde, Chris
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description Greater clarity on the nature of clinical utility is desirable. Of itself it may not bring about greater use of tests, including WGS (whole-genome sequencing), not least because clinical utility studies when performed may not confirm predicted changes in patient outcome. The notion that single “pivotal” clinical utility studies will achieve uptake needs to be questioned and that the evidence base for tests is likely to rely on patchworks of imperfect evidence embraced.
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spelling pubmed-79334232021-03-19 Will better evidence on clinical utility bring about greater use of (genetic) tests? Hyde, Chris NPJ Genom Med Comment Greater clarity on the nature of clinical utility is desirable. Of itself it may not bring about greater use of tests, including WGS (whole-genome sequencing), not least because clinical utility studies when performed may not confirm predicted changes in patient outcome. The notion that single “pivotal” clinical utility studies will achieve uptake needs to be questioned and that the evidence base for tests is likely to rely on patchworks of imperfect evidence embraced. Nature Publishing Group UK 2021-03-04 /pmc/articles/PMC7933423/ /pubmed/33664270 http://dx.doi.org/10.1038/s41525-021-00187-8 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Comment
Hyde, Chris
Will better evidence on clinical utility bring about greater use of (genetic) tests?
title Will better evidence on clinical utility bring about greater use of (genetic) tests?
title_full Will better evidence on clinical utility bring about greater use of (genetic) tests?
title_fullStr Will better evidence on clinical utility bring about greater use of (genetic) tests?
title_full_unstemmed Will better evidence on clinical utility bring about greater use of (genetic) tests?
title_short Will better evidence on clinical utility bring about greater use of (genetic) tests?
title_sort will better evidence on clinical utility bring about greater use of (genetic) tests?
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933423/
https://www.ncbi.nlm.nih.gov/pubmed/33664270
http://dx.doi.org/10.1038/s41525-021-00187-8
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